Ignite Creation Date:
2024-05-06 @ 3:56 PM
Last Modification Date:
2024-10-26 @ 2:00 PM
Study NCT ID:
NCT04818164
Status:
COMPLETED
Last Update Posted:
2022-03-04
First Post:
2021-03-25
Brief Title:
Prone Position Improves End-Expiratory Lung Volumes in COVID-19 Acute Respiratory Distress Syndrome
Sponsor:
Istanbul University - Cerrahpasa IUC
Organization:
Istanbul University - Cerrahpasa IUC
Study Overview
Official Title:
Prone Position Improves End-Expiratory Lung Volumes in COVID-19 Associated Acute Respiratory Distress Syndrome An Observational Study
Status:
COMPLETED
Status Verified Date:
2022-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Covid-19 associated Acute Respiratory Distress Syndrome ARDS may present with profound hypoxemia not fully explained with pulmonary infiltrates Accordingly how prone positioning improves oxygenation in these patients is not fully known The investigators conducted a study among patients with severe Covid-19 ARDS receiving prone position for at least 16 hours End Expiratory Lung Volume EELV was measured with Nitrogen wash-inwash-out technique before Supine Position 1- SP1 during Prone Position - PP and after Supine Position 2 - SP2 prone positioning
Detailed Description:
After initiation of invasive mechanical ventilation initial ventilator settings were performed by the attending physician These settings include titration of best PEEP to promote oxygenation if Spo2 92 despite a Fio2 higher than 80 or best compliance that do not jeopardize oxygenation if Fio2 is between 50-80 and Spo2 92 After a period of 30 minutes for stabilisation the first set of measurements were done in the SP1 position Afterwards the patient was turned to prone position with the same PEEP which was unchanged throughout the study period and measurements were repeated every four hours until the patient was reverted back to SP2 Eventually there were 7 measurements in total SP1 PP0 PP4 PP8 PP12 PP16 SP2 Dead space ventilation and shunt fraction calculations were made based on central venous blood gas measurements and oxygen consumption and carbon dioxide production at the relevant timepoint
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None