Ignite Creation Date:
2024-05-06 @ 3:54 PM
Last Modification Date:
2024-10-26 @ 1:59 PM
Study NCT ID:
NCT04802889
Status:
COMPLETED
Last Update Posted:
2021-03-17
First Post:
2020-12-06
Brief Title:
Microarchitecture of Vitreoretinal Contact
Sponsor:
The SN Fyodorov Eye Microsurgery State Institution
Organization:
The SN Fyodorov Eye Microsurgery State Institution
Study Overview
Official Title:
Microarchitecture of Vitreoretinal Contact
Status:
COMPLETED
Status Verified Date:
2021-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Investigation of the vitreoretinal contact microarchitecture in the macular and paramacular zones of the human retina
Detailed Description:
Purpose to study the features of the macular ILM to study the features of the preretinal structures of the vitreous body of the Central retinal region morphofunctional features of preretinal hyalocytes and the mechanism of vitreoretinal adhesion
Study Protocol examination of donor human eyes obtained from an eye Bank after sampling material for corneal transplantation
Research method scanning electron microscopy SEM of the central retina macular and paramacular zone ILM preretinal vitreous
Scientific hypothesis vitreoretinal adhesion is provided not by laminin and fibronectin but by the interweaving of vitreous collagen fibers between the epiretinal vitreous more firmly fixed to the retinal surface and the cortical vitreous
Expected results determination of ILM thickness in the macular zone microanatomy of preretinal vitreous strutcures and possible mechanism of vitreoretinal adhesion establishing the possibility of intravital synthesis of collagen fibers synthesis in the adult vitreous
Study Protocol examination of donor human eyes obtained from an eye Bank after sampling material for corneal transplantation
Research method scanning electron microscopy SEM of the central retina macular and paramacular zone ILM preretinal vitreous
Scientific hypothesis vitreoretinal adhesion is provided not by laminin and fibronectin but by the interweaving of vitreous collagen fibers between the epiretinal vitreous more firmly fixed to the retinal surface and the cortical vitreous
Expected results determination of ILM thickness in the macular zone microanatomy of preretinal vitreous strutcures and possible mechanism of vitreoretinal adhesion establishing the possibility of intravital synthesis of collagen fibers synthesis in the adult vitreous
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None