Ignite Creation Date:
2024-05-06 @ 3:54 PM
Last Modification Date:
2024-10-26 @ 1:59 PM
Study NCT ID:
NCT04799834
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2023-12-19
First Post:
2021-03-11
Brief Title:
Genotype and Susceptibility to COVID-19
Sponsor:
Mario Negri Institute for Pharmacological Research
Organization:
Mario Negri Institute for Pharmacological Research
Study Overview
Official Title:
Study of the Genetic Factors That Influence the Susceptibility to and Severity of COVID-19
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ORIGIN
Brief Summary:
COVID-19 is a viral disease induced by infection with the novel SARS-CoV-2 coronavirus Infection arises from the inhalation of viral particles spread by an infected individual The main virus entry pathways are the nose and mouth mucous membranes particularly rich in ACE2 receptors that are used by the virus to enter cells and begin its replication
Not all individuals who contract the virus fall ill and most of those who do about 70-80 experience mild symptoms fever cough headache muscle aches loss of taste and smell If the immune system is unable to rapidly fight the virus back the latter can attack the lungs affeting oxygen absorption inside the alveoli and lead to pneumonia This more severe form is observed in 20 of patients and can develop into even more serious complications requiring intensive care with a high mortality rate In severe cases about 5 the disease spreads to the entire body reaching the cardiovascular system and brain with the risk of heart attacks encephalitis and stroke but it can also affect the liver kidney and bowel
Reasons why some subjects develop a highly severe disease while others have little or no symptoms at all still remain unclear Many researchers are trying to find an answer by investigating the human genome and the Mario Negri laboratories are also working in this direction
The general hypothesis underlying this research project is that inter-individual genetic variations can explain the different responses to viral infection in a population and that COVID-19 severity is therefore genetically determined in each infected subject
Not all individuals who contract the virus fall ill and most of those who do about 70-80 experience mild symptoms fever cough headache muscle aches loss of taste and smell If the immune system is unable to rapidly fight the virus back the latter can attack the lungs affeting oxygen absorption inside the alveoli and lead to pneumonia This more severe form is observed in 20 of patients and can develop into even more serious complications requiring intensive care with a high mortality rate In severe cases about 5 the disease spreads to the entire body reaching the cardiovascular system and brain with the risk of heart attacks encephalitis and stroke but it can also affect the liver kidney and bowel
Reasons why some subjects develop a highly severe disease while others have little or no symptoms at all still remain unclear Many researchers are trying to find an answer by investigating the human genome and the Mario Negri laboratories are also working in this direction
The general hypothesis underlying this research project is that inter-individual genetic variations can explain the different responses to viral infection in a population and that COVID-19 severity is therefore genetically determined in each infected subject
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None