Ignite Creation Date:
2024-05-06 @ 3:53 PM
Last Modification Date:
2024-10-26 @ 1:59 PM
Study NCT ID:
NCT04792047
Status:
COMPLETED
Last Update Posted:
2021-03-10
First Post:
2021-02-25
Brief Title:
Pericoronary Fat Attenuation Index and High-risk Plaque in Patients With Acute Coronary Syndrome
Sponsor:
RenJi Hospital
Organization:
RenJi Hospital
Study Overview
Official Title:
Increased Pericoronary Fat Attenuation Index is Associated With High-risk Plaque and Local Immune-inflammatory Activation in Patients With Non-ST Elevation Acute Coronary Syndrome
Status:
COMPLETED
Status Verified Date:
2021-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aimed to investigate the relationship between CCTA-based pericoronary inflammation and plaque features as well as local immune-inflammatory biomarkers in ACS patients It is hypothesized that perivascular FAI might serve as a reliable sensor of coronary immune-inflammatory disorder and closely related to the plaque vulnerability
Detailed Description:
The pericoronary fat attenuation index FAI which capture by standard coronary computed tomography angiography CCTA has emerged as a novel imaging biomarker of coronary inflammation This study aimed to assess whether increased Pericoronary FAI on CCTA are associated with high-risk plaque HRP feature as well as local T cell subsets and their intracellular cytokines levels in non-ST elevation acute coronary syndromes ACS patients 195 lesions in 130 non-ST elevation ACS patients were prospectively enrolled and evaluated by CCTA and coronary angiography in this study Blood were taken from coronary artery immediately after the diagnostic angiogram Local T cell subsets and their intracellular cytokines levels were detected by Flow Cytometry CCTA and pericoronary FAI examinations were performed using a 320-detecor Aquilion ONE Toshiba Medical Systems Otawara Japan Systems Coronary plaque characteristics were analyzed cross each of the main coronary arteries using commercialized software package Qangio CT Medis The Netherlands
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None