Ignite Creation Date:
2024-05-06 @ 3:53 PM
Last Modification Date:
2025-12-17 @ 12:26 PM
Study NCT ID:
NCT04790968
Status:
None
Last Update Posted:
2024-11-15 00:00:00
First Post:
2021-03-05 00:00:00
Brief Title:
Combined PSMA PET/MRI for Detection of Lymph Node Metastases in High-risk Prostate Cancer Patients
Sponsor:
Norwegian University of Science and Technology
Organization:
Norwegian University of Science and Technology
Study Overview
Official Title:
Combined PSMA PET/MRI for Detection of Lymph Node Metastases in High-risk Prostate Cancer Patients
Status:
None
Status Verified Date:
2024-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
High-risk prostate cancer patients have a high probability for lymph node metastases in the pelvic region. The lymph node status is an important prognostic factor in determining the risk of later relapses and a factor in treatment planning. Lymph node metastases outside the pelvis usually signify systemic treatment not amendable for curative treatment.
High-risk prostate cancer patients are treated by radiotherapy or surgical resection of the prostate and the pelvic lymph nodes. Currently, the most reliable method for confirming lymph node metastases is by bilateral pelvic lymph node dissection during surgical treatment, and subsequent histologic examination. However, todays state-of-the art methods for the detection of lymph node metastases prior to treatment are clearly inadequate. Detection of lymph node metastases is crucial for determining whether the patient (i) is a candidate for localized treatment and, if so, (ii) optimizing the extent of the lymph node dissection / radiation field for localized treatment. Non-standard imaging methods such as prostate specific membrane antigen (PSMA)-PET-imaging have been shown to be able to aid in the detection of lymph node metastases. The purpose of this study is to test whether PSMA-PET or a combination of PSMA-PET and MRI can improve the sensitivity and specificity for pre-treatment lymph node staging in order to reduce both over- and undertreatment of high-risk prostate cancer patients.
In this multi-centre study, at least 80 patients with high-grade prostate cancer (according to NCNN Guidelines, v 2.2022) will be examined with PSMA PET/MRI and PET/CT. Study recruitment will continue until 60 patients have received radial prostatectomy with extended pelvic lymph node dissection (ePLND) (surgery cohort) and 20 patients have been treated with radiotherapy to the prostate and pelvic lymph nodes (radiotherapy cohort). After the PET examinations, all patients will receive standard treatment and follow-up, which is determined by national guidelines and the patient's treating urologist and/or oncologist. Imaging data will be analyzed by radiologists and nuclear medicine physicians in collaboration. The imaging findings in the surgery cohort will be compared to the histology outcome after ePLND to assess the sensitivity and specificity for detection of lymph node involvement with PSMA PET/MRI. The data from the radiotherapy cohort will be used to assess the feasibility of PSMA PET/MRI-based radiotherapy planning. Advanced image processing and analysis methodology including the use of artificial intelligence will also be applied.
High-risk prostate cancer patients are treated by radiotherapy or surgical resection of the prostate and the pelvic lymph nodes. Currently, the most reliable method for confirming lymph node metastases is by bilateral pelvic lymph node dissection during surgical treatment, and subsequent histologic examination. However, todays state-of-the art methods for the detection of lymph node metastases prior to treatment are clearly inadequate. Detection of lymph node metastases is crucial for determining whether the patient (i) is a candidate for localized treatment and, if so, (ii) optimizing the extent of the lymph node dissection / radiation field for localized treatment. Non-standard imaging methods such as prostate specific membrane antigen (PSMA)-PET-imaging have been shown to be able to aid in the detection of lymph node metastases. The purpose of this study is to test whether PSMA-PET or a combination of PSMA-PET and MRI can improve the sensitivity and specificity for pre-treatment lymph node staging in order to reduce both over- and undertreatment of high-risk prostate cancer patients.
In this multi-centre study, at least 80 patients with high-grade prostate cancer (according to NCNN Guidelines, v 2.2022) will be examined with PSMA PET/MRI and PET/CT. Study recruitment will continue until 60 patients have received radial prostatectomy with extended pelvic lymph node dissection (ePLND) (surgery cohort) and 20 patients have been treated with radiotherapy to the prostate and pelvic lymph nodes (radiotherapy cohort). After the PET examinations, all patients will receive standard treatment and follow-up, which is determined by national guidelines and the patient's treating urologist and/or oncologist. Imaging data will be analyzed by radiologists and nuclear medicine physicians in collaboration. The imaging findings in the surgery cohort will be compared to the histology outcome after ePLND to assess the sensitivity and specificity for detection of lymph node involvement with PSMA PET/MRI. The data from the radiotherapy cohort will be used to assess the feasibility of PSMA PET/MRI-based radiotherapy planning. Advanced image processing and analysis methodology including the use of artificial intelligence will also be applied.
Detailed Description:
High-risk prostate cancer patients have a high probability for lymph node metastases in the pelvic region The lymph node status is an important prognostic factor in determining the risk of later relapses and a factor in treatment planning Lymph node metastases outside the pelvis usually signify systemic treatment not amendable for curative treatment
High-risk prostate cancer patients are treated by radiotherapy or surgical resection of the prostate and the pelvic lymph nodes Currently the most reliable method for confirming lymph node metastases is by bilateral pelvic lymph node dissection during surgical treatment and subsequent histologic examination However todays state-of-the art methods for the detection of lymph node metastases prior to treatment are clearly inadequate Detection of lymph node metastases is crucial for determining whether the patient i is a candidate for localized treatment and if so ii optimizing the extent of the lymph node dissection radiation field for localized treatment Non-standard imaging methods such as prostate specific membrane antigen PSMA-PET-imaging have been shown to be able to aid in the detection of lymph node metastases The purpose of this study is to test whether PSMA-PET or a combination of PSMA-PET and MRI can improve the sensitivity and specificity for pre-treatment lymph node staging in order to reduce both over- and undertreatment of high-risk prostate cancer patients
In this multi-centre study at least 80 patients with high-grade prostate cancer according to NCNN Guidelines v 22022 will be examined with PSMA PETMRI and PETCT Study recruitment will continue until 60 patients have received radial prostatectomy with extended pelvic lymph node dissection ePLND surgery cohort and 20 patients have been treated with radiotherapy to the prostate and pelvic lymph nodes radiotherapy cohort After the PET examinations all patients will receive standard treatment and follow-up which is determined by national guidelines and the patients treating urologist andor oncologist Imaging data will be analyzed by radiologists and nuclear medicine physicians in collaboration The imaging findings in the surgery cohort will be compared to the histology outcome after ePLND to assess the sensitivity and specificity for detection of lymph node involvement with PSMA PETMRI The data from the radiotherapy cohort will be used to assess the feasibility of PSMA PETMRI-based radiotherapy planning Advanced image processing and analysis methodology including the use of artificial intelligence will also be applied
High-risk prostate cancer patients are treated by radiotherapy or surgical resection of the prostate and the pelvic lymph nodes Currently the most reliable method for confirming lymph node metastases is by bilateral pelvic lymph node dissection during surgical treatment and subsequent histologic examination However todays state-of-the art methods for the detection of lymph node metastases prior to treatment are clearly inadequate Detection of lymph node metastases is crucial for determining whether the patient i is a candidate for localized treatment and if so ii optimizing the extent of the lymph node dissection radiation field for localized treatment Non-standard imaging methods such as prostate specific membrane antigen PSMA-PET-imaging have been shown to be able to aid in the detection of lymph node metastases The purpose of this study is to test whether PSMA-PET or a combination of PSMA-PET and MRI can improve the sensitivity and specificity for pre-treatment lymph node staging in order to reduce both over- and undertreatment of high-risk prostate cancer patients
In this multi-centre study at least 80 patients with high-grade prostate cancer according to NCNN Guidelines v 22022 will be examined with PSMA PETMRI and PETCT Study recruitment will continue until 60 patients have received radial prostatectomy with extended pelvic lymph node dissection ePLND surgery cohort and 20 patients have been treated with radiotherapy to the prostate and pelvic lymph nodes radiotherapy cohort After the PET examinations all patients will receive standard treatment and follow-up which is determined by national guidelines and the patients treating urologist andor oncologist Imaging data will be analyzed by radiologists and nuclear medicine physicians in collaboration The imaging findings in the surgery cohort will be compared to the histology outcome after ePLND to assess the sensitivity and specificity for detection of lymph node involvement with PSMA PETMRI The data from the radiotherapy cohort will be used to assess the feasibility of PSMA PETMRI-based radiotherapy planning Advanced image processing and analysis methodology including the use of artificial intelligence will also be applied
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None