Ignite Creation Date:
2024-05-06 @ 3:53 PM
Last Modification Date:
2024-10-26 @ 1:59 PM
Study NCT ID:
NCT04798092
Status:
UNKNOWN
Last Update Posted:
2022-12-05
First Post:
2021-01-29
Brief Title:
Impact of Parathyroidectomy on Renal Function
Sponsor:
Central Hospital Nancy France
Organization:
Central Hospital Nancy France
Study Overview
Official Title:
Impact of Parathyroidectomy on Renal Function in Patients With Primary Hyperparathyroidism
Status:
UNKNOWN
Status Verified Date:
2022-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PARA-REIN
Brief Summary:
Primary hyperparathyroidism PHPT is a disorder of one or more of the parathyroid glands The parathyroid glands becomes overactive and secretes excess amounts of parathyroid hormone PTH As a result the blood calcium rises to a level that is higher than normal PHPT is associated with several other metabolic complications as osteoporosis kidney stones hypertension insulin resistance cardiac calcifications cardiac arrhythmias and kidney failure Renal function deterioration over time has also been reported However the role of parathyroidectomy on renal function remains controversial in patients with PHPT In some studies surgical cure of PHPT has been shown to halt renal function deterioration in patients with coexisting renal disease On the other hand other studies showed no significant impact of parathyroidectomy on renal function Consequently the goal of this study was to evaluate renal function before and after parathyroidectomy in a large cohort of patients with pHPT
Detailed Description:
Primary hyperparathyroidism PHPT is a disorder of one or more of the parathyroid glands The parathyroid glands becomes overactive and secretes excess amounts of parathyroid hormone PTH As a result the blood calcium rises to a level that is higher than normal PHPT is associated with several other metabolic complications as osteoporosis kidney stones hypertension insulin resistance cardiac calcifications cardiac arrhythmias and kidney failure Renal function deterioration over time has also been reported However the role of parathyroidectomy on renal function remains controversial in patients with PHPT In some studies surgical cure of PHPT has been shown to halt renal function deterioration in patients with coexisting renal disease On the other hand other studies showed no significant impact of parathyroidectomy on renal function Consequently the goal of this study was to evaluate renal function before and after parathyroidectomy in a large cohort of patients with pHPT
Criteria are detailled in Outcomes measures
Criteria are detailled in Outcomes measures
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None