Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005355
Status:
COMPLETED
Last Update Posted:
2016-03-02
First Post:
2000-05-25
Brief Title:
Gender Differences in Familial Risk
Sponsor:
Virginia Commonwealth University
Organization:
Virginia Commonwealth University
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2016-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To develop test and apply comprehensive mathematical models for the interaction of genetic and environmental effect on cardiovascular risk with gender differences
Detailed Description:
DESIGN NARRATIVE
Models were developed which allowed for sex difference in the expression of autosomal polygenes differences in the impact of the paternal and maternal environment on male and female offspring and for the complex consequences of assortative mating on the correlations among loci and between genes and environment Computer simulations were used to decide which kinds of gender-dependent effects could be resolved with particular constellations of relatives and to address problems of power and bias resulting from errors of model-specification The methods developed were applied to data from extensive data already gathered from twins and their relatives to determine the importance of sex differences in genetic and environmental causes of variation in measured aspects of cardiovascular risk including weight body-mass index family history of CV disease smoking alcohol consumption exercise diet psychosocial variables and lifestyle
Models were developed which allowed for sex difference in the expression of autosomal polygenes differences in the impact of the paternal and maternal environment on male and female offspring and for the complex consequences of assortative mating on the correlations among loci and between genes and environment Computer simulations were used to decide which kinds of gender-dependent effects could be resolved with particular constellations of relatives and to address problems of power and bias resulting from errors of model-specification The methods developed were applied to data from extensive data already gathered from twins and their relatives to determine the importance of sex differences in genetic and environmental causes of variation in measured aspects of cardiovascular risk including weight body-mass index family history of CV disease smoking alcohol consumption exercise diet psychosocial variables and lifestyle
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL048148 | NIH | None | httpsreporternihgovquickSearchR01HL048148 |