Ignite Creation Date:
2024-05-06 @ 3:51 PM
Last Modification Date:
2024-10-26 @ 1:58 PM
Study NCT ID:
NCT04785469
Status:
COMPLETED
Last Update Posted:
2022-12-16
First Post:
2021-03-02
Brief Title:
Eccentric Training in Individuals With COPD
Sponsor:
Fondazione Don Carlo Gnocchi Onlus
Organization:
Fondazione Don Carlo Gnocchi Onlus
Study Overview
Official Title:
Impact of a Low-load Eccentric Training Program on Peripheral Muscle Function in Patients With Chronic Obstructive Pulmonary Disease
Status:
COMPLETED
Status Verified Date:
2022-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Skeletal muscle dysfunction as a systemic consequence of chronic obstructive pulmonary disease COPD has a major impact on quality of life health care resource utilization and mortality of patients with this disease In fact a vicious circle of inactivity and disuse is established in the advanced stages of the disease inducing a progressive decline in exercise tolerance and a loss of muscle mass especially in locomotor muscles resulting in the inability of patients to perform even the simplest daily activities
In this context the multidisciplinary rehabilitation approach includes not only recovery of exercise capacity but also training aimed at restoring muscle function in patients with COPD However there is considerable methodological variability among muscle resistance training programs used in clinical practice with patients with COPD This is compounded by the need to identify alternative training strategies effective in inducing functional adaptation in skeletal muscle without increasing the degree of dyspnea or fatigue in those symptomatic patients with advanced stages of disease Among these eccentric exercise or negative work ie the stretching of the muscle during the active contraction phase represents a valid alternative to traditional concentric training in various rehabilitation contexts The main advantages of this training method are 1 eccentric contraction is able to produce greater forces than isometric and concentric contraction 2 for the same resistance eccentric contraction has a lower metabolic cost than concentric contraction For these reasons eccentric exercise is a valid method of muscle strengthening in rehabilitation and in particular in those subjects unable to sustain a high cardiorespiratory effort as in the case of patients with moderate-severe COPD Previous studies have also shown that eccentric exercise even at low load produces results equivalent if not superior to traditional training with respect to some particular characteristics of muscle function such as power and hypertrophy
However eccentric training programs for muscle dysfunction recovery in patients with COPD are underused in clinical practice so far In contrast the so called iso-weight eccentric training more suitable for clinical practice could also be applied to rehabilitation programs designed for COPD patients
The aim of this study is therefore to evaluate the reliability and efficacy of a low-load eccentric exercise training program compared to usual care for the improvement of muscle function in patients with COPD
In this context the multidisciplinary rehabilitation approach includes not only recovery of exercise capacity but also training aimed at restoring muscle function in patients with COPD However there is considerable methodological variability among muscle resistance training programs used in clinical practice with patients with COPD This is compounded by the need to identify alternative training strategies effective in inducing functional adaptation in skeletal muscle without increasing the degree of dyspnea or fatigue in those symptomatic patients with advanced stages of disease Among these eccentric exercise or negative work ie the stretching of the muscle during the active contraction phase represents a valid alternative to traditional concentric training in various rehabilitation contexts The main advantages of this training method are 1 eccentric contraction is able to produce greater forces than isometric and concentric contraction 2 for the same resistance eccentric contraction has a lower metabolic cost than concentric contraction For these reasons eccentric exercise is a valid method of muscle strengthening in rehabilitation and in particular in those subjects unable to sustain a high cardiorespiratory effort as in the case of patients with moderate-severe COPD Previous studies have also shown that eccentric exercise even at low load produces results equivalent if not superior to traditional training with respect to some particular characteristics of muscle function such as power and hypertrophy
However eccentric training programs for muscle dysfunction recovery in patients with COPD are underused in clinical practice so far In contrast the so called iso-weight eccentric training more suitable for clinical practice could also be applied to rehabilitation programs designed for COPD patients
The aim of this study is therefore to evaluate the reliability and efficacy of a low-load eccentric exercise training program compared to usual care for the improvement of muscle function in patients with COPD
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None