Ignite Creation Date:
2024-05-06 @ 3:51 PM
Last Modification Date:
2024-10-26 @ 1:58 PM
Study NCT ID:
NCT04781569
Status:
COMPLETED
Last Update Posted:
2021-06-03
First Post:
2021-02-23
Brief Title:
Staphylococcus Aureus Caught in Action at the Site of Infection
Sponsor:
University Hospital Basel Switzerland
Organization:
University Hospital Basel Switzerland
Study Overview
Official Title:
A Single Centre Unblinded Prospective Cohort Study Identifying Pathogen Adaptations in Patients Suffering From Invasive S Aureus Infection Compared to Colonized Healthy Individuals
Status:
COMPLETED
Status Verified Date:
2021-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PROSA
Brief Summary:
This study is to obtain a comprehensive view of S aureus adaptations in the infected human host and i to improve the understanding of the interface between antibiotic therapy resistance development and virulence factor adaptation in S aureus infected patients and ii to adapt these findings into a more sustainable use of antimicrobials for therapy
Detailed Description:
Staphylococcus S aureus is notorious for its ability to develop resistance This study is to obtain a comprehensive view of S aureus adaptations in the infected human host and i to improve the understanding of the interface between antibiotic therapy resistance development and virulence factor adaptation in S aureus infected patients and ii to adapt these findings into a more sustainable use of antimicrobials for therapy
Patients with S aureus infections who will routinely undergo diagnostic and surgical procedures will be identified Intraoperative samples from the site of infection during surgery will be taken Additionally two blood drawing events 225ml in total will be performed and nose swabs will be taken The biological material will be analysed This project will be the first to study different phenotypes of invasive S aureus directly from its environment in vivo
Patients with S aureus infections who will routinely undergo diagnostic and surgical procedures will be identified Intraoperative samples from the site of infection during surgery will be taken Additionally two blood drawing events 225ml in total will be performed and nose swabs will be taken The biological material will be analysed This project will be the first to study different phenotypes of invasive S aureus directly from its environment in vivo
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None