Ignite Creation Date:
2024-05-06 @ 3:51 PM
Last Modification Date:
2024-10-26 @ 1:58 PM
Study NCT ID:
NCT04774120
Status:
COMPLETED
Last Update Posted:
2022-03-16
First Post:
2021-01-19
Brief Title:
Relationship Between Bispectral Index EEG Features and Propofol Effect-site Concentration in Young and Elderly Patients
Sponsor:
Pontificia Universidad Catolica de Chile
Organization:
Pontificia Universidad Catolica de Chile
Study Overview
Official Title:
Relationship Between Bispectral Index EEG Features and Propofol Effect-site Concentration in Young and Elderly Patients
Status:
COMPLETED
Status Verified Date:
2021-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to describe the BIS values and electroencephalographic patterns during total intravenous anesthesia with propofol-remifentanyl in patients from 18 to 85 years
Detailed Description:
Propofol is an anesthetic drug regularly used in elderly patients requiring anesthesia The electroencephalographic pattern recognized when propofol is administered is different from the pattern obtained in younger patients Both groups present alpha and slow delta bands but younger patients present more intense electroencephalographic bands than older patients 1 The correlation between BIS values and the power of electroencephalographic frequency bands during propofol-remifentanyl anesthesia has not been determined
The investigators will describe the changes in BIS values and electroencephalographic patterns in young and elderly patients receiving propofol-remifentanyl anesthesia for elective surgery at different propofol concentration levels Formal characterization of the dynamic relationship between propofol concentrations at the effect site Ce spectral power and BIS values may provide clinically relevant information to design propofol dose schemes in elderly patients
The investigators will carry out a prospective observational clinical study at the Clinical Hospital of the Catholic University of Chile 30 patients aged 18-85 years scheduled to undergo elective surgery will be recruited Standard monitoring and 2 frontal EEG monitors will be installed Sedline and BIS The electroencephalographic signal from these monitors will be recorded simultaneously from anesthesia induction until extubation Propofol will be started at a rate of 15-20 mgkghr in patients 65 years and 20-25 mgkghr in younger patients 65 years until a suppression rate SR 1 appears in the BIS EEG monitor If the SR is not achieved the infusion rate can be increased by 5 mgkghr every 5 minutes until 25 mgkghr in the elderly group and 30 mgkghr in the younger group When the SR appears propofol infusion will be stopped The induction phase will be considered completed at this point Loss of response LOR defined as the timepoint when patients became unresponsive to verbal commands soft shaking and eyelash reflex will be assessed every 30 seconds When patients become apneic positive pressure mask ventilation will be started gently at a rate of 10 breaths per minute After induction of anesthesia opioids and neuromuscular blocking drugs will be given to facilitate tracheal intubation When BIS values increase to recommended hypnotic levels for surgery 40-60 the propofol infusion rate will be started again at half of the induction rate This rate will be adjusted to maintain the alpha band present in the Sedline spectrogram and SEF95 between 8-12 Hz BIS monitor will be covered and hidden from the attending anesthesiologist during the maintenance phase After surgery ends EEG monitoring will continue until the patients extubation One hour after extubation the Brice questionnaire will be performed to detect intraoperative awakening Propofol concentration will be estimated using the Schnider model
The investigators will describe the changes in BIS values and electroencephalographic patterns in young and elderly patients receiving propofol-remifentanyl anesthesia for elective surgery at different propofol concentration levels Formal characterization of the dynamic relationship between propofol concentrations at the effect site Ce spectral power and BIS values may provide clinically relevant information to design propofol dose schemes in elderly patients
The investigators will carry out a prospective observational clinical study at the Clinical Hospital of the Catholic University of Chile 30 patients aged 18-85 years scheduled to undergo elective surgery will be recruited Standard monitoring and 2 frontal EEG monitors will be installed Sedline and BIS The electroencephalographic signal from these monitors will be recorded simultaneously from anesthesia induction until extubation Propofol will be started at a rate of 15-20 mgkghr in patients 65 years and 20-25 mgkghr in younger patients 65 years until a suppression rate SR 1 appears in the BIS EEG monitor If the SR is not achieved the infusion rate can be increased by 5 mgkghr every 5 minutes until 25 mgkghr in the elderly group and 30 mgkghr in the younger group When the SR appears propofol infusion will be stopped The induction phase will be considered completed at this point Loss of response LOR defined as the timepoint when patients became unresponsive to verbal commands soft shaking and eyelash reflex will be assessed every 30 seconds When patients become apneic positive pressure mask ventilation will be started gently at a rate of 10 breaths per minute After induction of anesthesia opioids and neuromuscular blocking drugs will be given to facilitate tracheal intubation When BIS values increase to recommended hypnotic levels for surgery 40-60 the propofol infusion rate will be started again at half of the induction rate This rate will be adjusted to maintain the alpha band present in the Sedline spectrogram and SEF95 between 8-12 Hz BIS monitor will be covered and hidden from the attending anesthesiologist during the maintenance phase After surgery ends EEG monitoring will continue until the patients extubation One hour after extubation the Brice questionnaire will be performed to detect intraoperative awakening Propofol concentration will be estimated using the Schnider model
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
True
Is an FDA AA801 Violation?:
None