Ignite Creation Date:
2024-05-05 @ 5:19 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00431587
Status:
UNKNOWN
Last Update Posted:
2008-04-17
First Post:
2007-02-05
Brief Title:
Changes in Different Fat Compartments and Their Effect on Particular Manifestations of Metabolic Syndrome After Bariatric Procedures
Sponsor:
Hadassah Medical Organization
Organization:
Hadassah Medical Organization
Study Overview
Official Title:
Changes in Different Fat Compartments During Weight Loss and Their Effect on Particular Manifestations of Metabolic Syndrome After Bariatric Procedures
Status:
UNKNOWN
Status Verified Date:
2007-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The metabolic risks associated with obesity are closely correlated with central abdominal rather than a peripheral gluteofemoral fat pattern It has been shown that weight loss after bariatric surgery is followed by metabolic improvements
The amount of fat lost from each site may be independently regulated Very scant information is found in the literature regarding the relative changes in different fat body compartments and their effect on the improvement of the metabolic profile
In this study we define the absolute and relative changes in the different adipose tissue compartment after weight loss surgery
The amount of fat lost from each site may be independently regulated Very scant information is found in the literature regarding the relative changes in different fat body compartments and their effect on the improvement of the metabolic profile
In this study we define the absolute and relative changes in the different adipose tissue compartment after weight loss surgery
Detailed Description:
The metabolic risks associated with obesity are closely correlated with central abdominal rather than a peripheral gluteofemoral fat pattern
The amount of fat lost from each site may be independently regulated Very scant information is found in the literature regarding the relative changes in different fat body compartments
Rapid and preferential reduction of visceral fat mass could occur in morbid obese with visceral obesity It has been previously shown and it was also partially confirmed in this study that a reduction in visceral fat was associated with metabolic improvements that included improved glucose tolerance and reduced plasma insulin and lipid levels
This again suggests a threshold of proportional visceral fat loss above which there is an improvement in insulin sensitivity and other component of metabolic syndrom
We will quantify the different fat compartments changes after bariatric surgery by means of CT scan
The amount of fat lost from each site may be independently regulated Very scant information is found in the literature regarding the relative changes in different fat body compartments
Rapid and preferential reduction of visceral fat mass could occur in morbid obese with visceral obesity It has been previously shown and it was also partially confirmed in this study that a reduction in visceral fat was associated with metabolic improvements that included improved glucose tolerance and reduced plasma insulin and lipid levels
This again suggests a threshold of proportional visceral fat loss above which there is an improvement in insulin sensitivity and other component of metabolic syndrom
We will quantify the different fat compartments changes after bariatric surgery by means of CT scan
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None