Ignite Creation Date:
2024-05-06 @ 3:50 PM
Last Modification Date:
2024-10-26 @ 1:58 PM
Study NCT ID:
NCT04775238
Status:
UNKNOWN
Last Update Posted:
2021-03-03
First Post:
2021-02-22
Brief Title:
Effect of Metallic Nanoparticles on Nosocomial Bacteria
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Metallic Nanoparticles Evaluation of Their Antibacterial Antibiofilm and Synergistic Effect in Combination With Antibiotics on Nosocomial Bacteria
Status:
UNKNOWN
Status Verified Date:
2021-02
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This research aims to study the properties of metallic nanoparticlesMNPs silver nanoparticles AgNps and copper nanoparticles CuNps on the 2 most common nosocomial bacteria which are highly resistant to antibiotics including Staphylococcus aureus and Pseudomonas aeruginosa to evaluate the growth inhibiting properties of MNPs on all bacterial isolates to evaluate the biofilm inhibitory effect on biofilm forming bacterial isolates and the synergistic effect of these MNPs in combination with antibiotics on the antibiotic resistant isolates
Detailed Description:
There is a rapid increase in the number of health care associated infections HAIs due to multi-drug resistant MDR bacterial strains which have a worse prognosis being associated with significant morbidity and mortality particularly in critically ill patients The main problem with MDR strains is their limited treatment options posing a major challenge for health care providersThe increasing utilization and immense studies of nanoparticles have brought new perspectives towards new antimicrobial material that could hinder the MDR bacteria pandemic currently faced Particularly metallic nanoparticles exhibit strong biocidal properties on different bacterial species including MDR bacteria Another important aspect of the antimicrobial properties of metallic nanoparticles is their potential to eradicate or inhibit microbial biofilm formation which is an important virulence factor in many localized chronic infections
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None