Ignite Creation Date:
2024-05-06 @ 3:50 PM
Last Modification Date:
2024-10-26 @ 1:58 PM
Study NCT ID:
NCT04776291
Status:
RECRUITING
Last Update Posted:
2023-05-16
First Post:
2021-02-24
Brief Title:
Correlation of Pre- and Post-operative Cancer Imaging Techniques
Sponsor:
University of Strathclyde
Organization:
University of Strathclyde
Study Overview
Official Title:
PET-PATH Investigation of New Medical Imaging Techniques for Improving Lung Cancer Treatment
Status:
RECRUITING
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Various imaging modalities are used in medical diagnosis such as MRI CT and PET The images are sometimes acquired at different times and in different body positions and thus need to be aligned for precise diagnosis and treatment planning Different image modalities provide complementary information about the anatomical structure under study Image registration techniques enable multimodality images to be projected onto a common coordinate system so that these images can be aligned and spatial correspondences can be established between the images
This research project aims to investigate the information provided by functional PET and CT images about the tumour environment in lung cancer patients by registering functional PET and CT images with the pathology images acquired from the same patient On identification of specific region of interest on the functional imaging the investigators will then be able to interrogate the tumour biology In many cancers the tumour environment is usually composed of a heterogeneous mass of tissue The discrimination and classification of the carcinoma substructures is of paramount importance in the radiotherapy planning stage as a given treatment may be more or less suitable depending on the local characteristics of the tumour For instance in hypoxic regions areas inside the tumour with very low oxygen supply radiotherapy performs poorly and strategies to intensify treatment to those areas could be investigated
This project will develop a framework for automatic registration of pathology images which are taken from a surgically extracted lung tumour with the corresponding PETCT scan acquired from the patient before surgery The registration of these images is essential for the evaluation of the performance of different PET radiotracers
This research project aims to investigate the information provided by functional PET and CT images about the tumour environment in lung cancer patients by registering functional PET and CT images with the pathology images acquired from the same patient On identification of specific region of interest on the functional imaging the investigators will then be able to interrogate the tumour biology In many cancers the tumour environment is usually composed of a heterogeneous mass of tissue The discrimination and classification of the carcinoma substructures is of paramount importance in the radiotherapy planning stage as a given treatment may be more or less suitable depending on the local characteristics of the tumour For instance in hypoxic regions areas inside the tumour with very low oxygen supply radiotherapy performs poorly and strategies to intensify treatment to those areas could be investigated
This project will develop a framework for automatic registration of pathology images which are taken from a surgically extracted lung tumour with the corresponding PETCT scan acquired from the patient before surgery The registration of these images is essential for the evaluation of the performance of different PET radiotracers
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None