Ignite Creation Date:
2024-05-06 @ 3:49 PM
Last Modification Date:
2024-10-26 @ 1:57 PM
Study NCT ID:
NCT04764032
Status:
UNKNOWN
Last Update Posted:
2021-02-21
First Post:
2021-02-12
Brief Title:
Right Ventricular Dysfunction in Ventilated Patients With COVID-19
Sponsor:
University of Glasgow
Organization:
University of Glasgow
Study Overview
Official Title:
Right Ventricular Dysfunction in Ventilated Patients With COVID-19
Status:
UNKNOWN
Status Verified Date:
2021-02
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
COVID-RV
Brief Summary:
Using echocardiography to investigate the incidence of RV dysfunction in ventilated patients with COVID-19
Detailed Description:
INTRODUCTION Following the first reported cases in China there has been a worldwide pandemic of a new virus commonly known as Coronavirus The virus causes a number of conditions including cough high temperature painful muscles and breathing difficulties The disease the virus causes is known as Coronavirus Disease 2019 COVID-19 In the majority of cases these symptoms will get better without any treatment and without needing admission to hospital In a small proportion of cases the symptoms can be so bad that patients will need admission to hospital Of the group admitted to hospital an even smaller group approximately 5 of all confirmed coronavirus cases will need treatment in an intensive care unit This is often for severe breathing difficulties and sometimes requires the patient to be put on a breathing machine The breathing machine is also known as a life support machine or ventilator and needing its support is known as ventilation or being ventilated
In other conditions causing severe breathing difficulties requiring ventilation pressure can be put on the right side of the heart the right heart or right ventricle the part of the heart pumping blood to the lungs This can cause the right heart to fail struggling to pump blood forward and with a build-up of back pressure This is also known as right heart or ventricular dysfunction Patients needing ventilated who develop problems with the right heart are less likely to survive their intensive care stay No scientists have examined whether patients with COVID-19 requiring ventilation have problems with their right heart
METHODS Using noninvasive ultrasound scans of the heart echocardiography the investigators will explore whether ventilated patients in intensive care have problems with their right heart The investigators will also collect blood samples to look for damage to the heart during this time
AIMS The aim of this study is to determine how many patients with COVID-19 needing ventilation have problems with the right heart The investigators will explore if those patients with right heart problems are more likely to die by 30 days following their intensive care admission By examining clinical data the investigators will also look to see if any other conditions or treatments increase the risk of right heart problems By identifying right heart problems in these patients the investigators may be able to guide future studies to determine if any specific treatments targeted at protecting the right heart can improve outcomes in this patient group
In other conditions causing severe breathing difficulties requiring ventilation pressure can be put on the right side of the heart the right heart or right ventricle the part of the heart pumping blood to the lungs This can cause the right heart to fail struggling to pump blood forward and with a build-up of back pressure This is also known as right heart or ventricular dysfunction Patients needing ventilated who develop problems with the right heart are less likely to survive their intensive care stay No scientists have examined whether patients with COVID-19 requiring ventilation have problems with their right heart
METHODS Using noninvasive ultrasound scans of the heart echocardiography the investigators will explore whether ventilated patients in intensive care have problems with their right heart The investigators will also collect blood samples to look for damage to the heart during this time
AIMS The aim of this study is to determine how many patients with COVID-19 needing ventilation have problems with the right heart The investigators will explore if those patients with right heart problems are more likely to die by 30 days following their intensive care admission By examining clinical data the investigators will also look to see if any other conditions or treatments increase the risk of right heart problems By identifying right heart problems in these patients the investigators may be able to guide future studies to determine if any specific treatments targeted at protecting the right heart can improve outcomes in this patient group
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None