Ignite Creation Date:
2024-05-06 @ 3:49 PM
Last Modification Date:
2024-10-26 @ 1:57 PM
Study NCT ID:
NCT04762368
Status:
RECRUITING
Last Update Posted:
2024-03-12
First Post:
2021-02-13
Brief Title:
Learning Study Improving Vision in Adults With Macular Degeneration
Sponsor:
University of Waterloo
Organization:
University of Waterloo
Study Overview
Official Title:
Improving Vision in Adults With Macular Degeneration Study 2 The Effect of Concurrent Perceptual Learning and Brain Stimulation
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to test whether a kind of brain stimulation called anodal transcranial direct current stimulation a-tDCS can be combined with perceptual learning to improve the ability of people with age-related macular degeneration AMD or juvenile macular degeneration JMD to read words presented to them on a computer screen better than if perceptual learning alone were used
In addition secondary measures of visual acuity will also be examined to determine whether brain stimulation can allow patients to resolve finer details of an image The proposed treatment is the application of a-tDCS onto the participants head with brain stimulation aimed at Primary Visual Cortex toward the occipital pole while patients undergo six separate sessions of training The investigators will test the ability of participants to read words before the start of the training sessions pre test and after the completion of all training sessions post test This is a between-subjects design and half of the participants will receive true stimulation and the other half will receive sham stimulation The difference between the pre and post tests when receiving active stimulation will be compared to the difference when receiving sham stimulation because the sham stimulation is not expected to influence reading beyond a placebo The aim of the study is to examine the potential of concurrent brain stimulation and perceptual learning as an effective treatment for macular degeneration that may be used in conjunction with more traditional eye-based interventions The investigators hypothesize that the brain stimulation will enable higher performance in the reading task after and secondary measures after perceptual training due to an increase in the cortical excitability of the stimulated brain cells
In addition secondary measures of visual acuity will also be examined to determine whether brain stimulation can allow patients to resolve finer details of an image The proposed treatment is the application of a-tDCS onto the participants head with brain stimulation aimed at Primary Visual Cortex toward the occipital pole while patients undergo six separate sessions of training The investigators will test the ability of participants to read words before the start of the training sessions pre test and after the completion of all training sessions post test This is a between-subjects design and half of the participants will receive true stimulation and the other half will receive sham stimulation The difference between the pre and post tests when receiving active stimulation will be compared to the difference when receiving sham stimulation because the sham stimulation is not expected to influence reading beyond a placebo The aim of the study is to examine the potential of concurrent brain stimulation and perceptual learning as an effective treatment for macular degeneration that may be used in conjunction with more traditional eye-based interventions The investigators hypothesize that the brain stimulation will enable higher performance in the reading task after and secondary measures after perceptual training due to an increase in the cortical excitability of the stimulated brain cells
Detailed Description:
This study will be carried out in Ontario Canada University of Waterloo and Hong Kong The Hong Kong Polytechnic University There are two conditions Active brain stimulation perceptual training and shamplacebo brain stimulation perceptual training This study uses a between-subjects design such that half of all participants will be placed in the active stimulation group and half will be placed in the sham group
Participants will be recruited from university-affiliated clinics and local clinical practices Following full informed consent participants will complete baseline testing and clinical testing to confirm that they meet eligibility criteria including a diagnosis of macular degeneration without any additional eye disease impaired vision but with enough visual acuity that the computer monitor can still present readable word and no contraindications for brain stimulation interventions Eligible participants will then be randomized to either receiving the active stimulation during perceptual training or the placebo stimulation during perceptual training
The primary outcome measure is verbal reading accuracy for sentences presented on a computer screen following a Rapid Serial Visual Presentation RSVP task in which a single word is presented on the screen at a time Participants will freely observe the words and will indicate the words on the screen verbally The secondary outcome measures are contrast sensitivity and crowded and uncrowded visual acuity as measured by Freiburg Visual Acuity Contrast Test FrACT using the Landolt C stimulus The Cs gap will be oriented randomly and the participant will indicate the orientation of the stimulus Crowded visual acuity will be assessed with Landolt C surrounded by a solid ring while uncrowded visual acuity will be assessed with the Landolt C alone The Test of contrast sensitivity will measure the amount of contrast required relative to the background to identify the orientation of the C The Hong Kong Polytechnic University has an additional set of secondary outcome measures of temporal and spatial visual span Temporal visual span will be assessed using Chinese trigrams presented horizontally or vertically at the centre for a range of presentation times Spatial visual span will be assessed using Chinese trigrams presented horizontally or vertically at different character positions for a fixed presentation time Participants will be asked to recognize all three characters in a correct order
The study consists of 9 sessions plus 1 additional session particularly for Hong Kong Polytechnic University
Session 0 This session only applies for The Hong Kong Polytechnic university that horizontal and vertical temporal and spatial visual span will be collected
Session 1 The first session will include the clinical evaluation In addition the pre tests of all outcome measures will be collected RSVP performance crowded and uncrowded visual acuity contrast sensitivity
Sessions 2-7 Brain stimulation sessions Participants will undergo roughly 1 hour of perceptual training performing the RSVP task The first 25 minutes of this training will include either sham or active brain stimulation A given participant will receive the same kind of stimulation for all 6 training sessions
Session 8 No brain stimulation will occur Post test outcome measures will be collected RSVP performance crowded and uncrowded visual acuity contrast sensitivity horizontal and vertical temporal and spatial visual span
Session 9 30 day follow up 30 days after the final training session participants will again perform the outcome measures without brain stimulation to determine the long term benefit of the perceptual training brain stimulation
Participants will be recruited from university-affiliated clinics and local clinical practices Following full informed consent participants will complete baseline testing and clinical testing to confirm that they meet eligibility criteria including a diagnosis of macular degeneration without any additional eye disease impaired vision but with enough visual acuity that the computer monitor can still present readable word and no contraindications for brain stimulation interventions Eligible participants will then be randomized to either receiving the active stimulation during perceptual training or the placebo stimulation during perceptual training
The primary outcome measure is verbal reading accuracy for sentences presented on a computer screen following a Rapid Serial Visual Presentation RSVP task in which a single word is presented on the screen at a time Participants will freely observe the words and will indicate the words on the screen verbally The secondary outcome measures are contrast sensitivity and crowded and uncrowded visual acuity as measured by Freiburg Visual Acuity Contrast Test FrACT using the Landolt C stimulus The Cs gap will be oriented randomly and the participant will indicate the orientation of the stimulus Crowded visual acuity will be assessed with Landolt C surrounded by a solid ring while uncrowded visual acuity will be assessed with the Landolt C alone The Test of contrast sensitivity will measure the amount of contrast required relative to the background to identify the orientation of the C The Hong Kong Polytechnic University has an additional set of secondary outcome measures of temporal and spatial visual span Temporal visual span will be assessed using Chinese trigrams presented horizontally or vertically at the centre for a range of presentation times Spatial visual span will be assessed using Chinese trigrams presented horizontally or vertically at different character positions for a fixed presentation time Participants will be asked to recognize all three characters in a correct order
The study consists of 9 sessions plus 1 additional session particularly for Hong Kong Polytechnic University
Session 0 This session only applies for The Hong Kong Polytechnic university that horizontal and vertical temporal and spatial visual span will be collected
Session 1 The first session will include the clinical evaluation In addition the pre tests of all outcome measures will be collected RSVP performance crowded and uncrowded visual acuity contrast sensitivity
Sessions 2-7 Brain stimulation sessions Participants will undergo roughly 1 hour of perceptual training performing the RSVP task The first 25 minutes of this training will include either sham or active brain stimulation A given participant will receive the same kind of stimulation for all 6 training sessions
Session 8 No brain stimulation will occur Post test outcome measures will be collected RSVP performance crowded and uncrowded visual acuity contrast sensitivity horizontal and vertical temporal and spatial visual span
Session 9 30 day follow up 30 days after the final training session participants will again perform the outcome measures without brain stimulation to determine the long term benefit of the perceptual training brain stimulation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None