Ignite Creation Date:
2024-05-06 @ 3:48 PM
Last Modification Date:
2024-10-26 @ 1:57 PM
Study NCT ID:
NCT04760262
Status:
COMPLETED
Last Update Posted:
2021-02-18
First Post:
2021-02-10
Brief Title:
The Effect of Anesthesia on Cerebral Oxygenation
Sponsor:
Karadeniz Technical University
Organization:
Karadeniz Technical University
Study Overview
Official Title:
The Effect of Different Anesthesia Techniques on Cerebral Oxygenation in Thoracic Surgery
Status:
COMPLETED
Status Verified Date:
2021-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
One-lung ventilation OLV may cause negative changes in the oxygenation of cerebral tissue which results in postoperative cognitive dysfunction The aim of this prospective study was to compare the potential effects of TIVA and inhalation general anesthesia techniques on cerebral tissue oxygenation and postoperative cognitive functions in patients receiving one-lung ventilation in thoracic surgery
Detailed Description:
One-lung ventilation OLV is a commonly used technique in thoracic surgeries In thoracic surgeries performed with OLV there may be changes in cerebral tissue oxygenation depending on both patient position and anesthetic technique The effect of cerebral hypoxia on postoperative cognitive functions is controversially Despite the ISPOCD1 study in which concluded that there were no relationship between the cerebral hypoxy and postoperative cognitive dysfunction POCD regional cerebral oxygen saturation decrements during surgery are listed among the POCD When OLV begins alveolar hypoxia and arteriovenous shunt of deoxygenated blood occur in the dependant lung And then hypoxic pulmonary vasoconstriction HPV in non-ventilated lung segments occurs with increased mechanical stress This event lead to significant physiological changes in cardiac output and pulmonary and systemic pressures In OLV the propofol-based total intravenous anesthesia TIVA and inhalation general anesthesia techniques are frequently used Recent studies have shown that unlike inhalational anesthetics propofol does not suppress HPV indeed increases it Inhalational anesthetic agents reduce cardiac output more than oxygen consumption causing a decrease in mixed venous partial pressure of oxygen which stimulates hypoxic pulmonary vasoconstriction Studies have shown significant reductions in cerebral oxygen saturation in thoracic surgery as a result of severe oxidative stress due to prolonged OLV and hypoxemia due to decreased functional residual capacity of the ventilated lung in the lateral decubitus position Cerebral oximetry is a method used to monitor the cerebral oxygen distribution-consumption balance and regional oxygen saturation rSO2 in a limited area of the frontal cortex by noninvasively and continuously combining arterial and venous oxygen saturation signals of near-infrared spectroscopy NIRS which is a technique developed in the 1970s Thanks to this method perioperative physiological conditions optimal tissue oxygenation and end-organ functions can be interpreted The aim of this prospective study was to compare the potential effects of TIVA and inhalation general anesthesia techniques on cerebral tissue oxygenation and postoperative cognitive functions in patients receiving one-lung ventilation in thoracic surgery
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None