Ignite Creation Date:
2024-05-06 @ 3:47 PM
Last Modification Date:
2024-10-26 @ 1:56 PM
Study NCT ID:
NCT04750330
Status:
COMPLETED
Last Update Posted:
2023-06-15
First Post:
2021-01-26
Brief Title:
Mitochondrial DNA and Nuclear SNPs to Predict Severity of COVID-19 Infection
Sponsor:
Maastricht University
Organization:
Maastricht University
Study Overview
Official Title:
Mitochondrial DNA and Nuclear SNPs to Predict Severity of COVID-19 Infection
Status:
COMPLETED
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
mtDNA-COVID
Brief Summary:
In December 2019 the first people got infected with COVID-19 in Wuhan China Within weeks this highly infectious disease spread all over the world Nearly one year later everyone is still trying to battle this disease and facing the consequences it causes What became clear is that the disease and its severity differs largely between infected people However knowledge about who will experience severe COVID-19 and who does not is still unclear Therefore the aim of this study is to investigate the prognostic value of certain parameters mtDNA and CT radiomics signature for the severity of COVID-19
Detailed Description:
In December 2019 the first cases of coronavirus disease 2019 COVID-19 were diagnosed in Wuhan China Within a couple of weeks the highly contagious disease spread across the world requiring rapid and drastic measures unparalleled in recent decades Currently there have been approximately 978 million cases including 21 million deaths reported to the WHO website accessed January 25th 2021 httpscovid19whoint Data from published epidemiology and virologic studies show that the virus is mainly passed on by respiratory droplets by direct contact with infected people or by contact with contaminated objects and surfaces The severity of the disease greatly differs between people It ranges from non-symptomatic contamination or minor symptoms such as a cold or sore throat to life-threatening pneumonia and death Especially the elderly population and people with underlying comorbidities are vulnerable and experience more severe symptoms In addition studies have shown that males have a higher mortality risk
COVID-19 is currently diagnosed using reverse-transcription polymerase chain reaction RT-PCR In the beginning of the pandemic the use of chest computed tomography CT was more common since CT can capture imaging features from the lung associated with COVID-19 early in the course of the disease However performing a CT-can takes remarkably longer than current RT-PCR tests While the epidemic continues the consequences are slowly becoming more apparent As the true population infection rate is unknown the proportion of patients requiring hospital admission is difficult to estimate In a meta-analysis including 1481 unique publications a pooled rate of ICU admission of 109 and the pooled rate of mortality was 43 The negative effects of an ICU stay strongly depend on the length of the stay and include but are not limited to risk of lung emboly severe muscle loss dysphagia and psychological problems often necessitating a long period of rehabilitation
To minimize long-term health consequences early prognosis of the severity of the disease would be beneficial The link between the severity of COVID-19 and mitochondrial DNA mtDNA Nuclear SNPs imaging features and radiomics has not been studied yet However literature about mechanistic insights in the functioning of the immune system and its link to genetic variation including mtDNA are promising In addition studies focusing on imaging features and radiomics have yielded interesting findings
COVID-19 is currently diagnosed using reverse-transcription polymerase chain reaction RT-PCR In the beginning of the pandemic the use of chest computed tomography CT was more common since CT can capture imaging features from the lung associated with COVID-19 early in the course of the disease However performing a CT-can takes remarkably longer than current RT-PCR tests While the epidemic continues the consequences are slowly becoming more apparent As the true population infection rate is unknown the proportion of patients requiring hospital admission is difficult to estimate In a meta-analysis including 1481 unique publications a pooled rate of ICU admission of 109 and the pooled rate of mortality was 43 The negative effects of an ICU stay strongly depend on the length of the stay and include but are not limited to risk of lung emboly severe muscle loss dysphagia and psychological problems often necessitating a long period of rehabilitation
To minimize long-term health consequences early prognosis of the severity of the disease would be beneficial The link between the severity of COVID-19 and mitochondrial DNA mtDNA Nuclear SNPs imaging features and radiomics has not been studied yet However literature about mechanistic insights in the functioning of the immune system and its link to genetic variation including mtDNA are promising In addition studies focusing on imaging features and radiomics have yielded interesting findings
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None