Ignite Creation Date:
2024-05-06 @ 3:47 PM
Last Modification Date:
2024-10-26 @ 1:57 PM
Study NCT ID:
NCT04757220
Status:
RECRUITING
Last Update Posted:
2023-08-21
First Post:
2021-01-12
Brief Title:
Multidimensional Apathy in Psychiatric Pathologies
Sponsor:
University Hospital Strasbourg France
Organization:
University Hospital Strasbourg France
Study Overview
Official Title:
Cognitive and Neural Mechanisms of Multidimensional Apathy in Psychiatric Pathologies
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AmSeD
Brief Summary:
Apathy is defined by quantitative decrease in goal-directed activity in comparison to the persons previous level of functioning Apathy is a transnosographic symptom prevalent in many neurological and psychiatric pathologies specifically in schizophrenia and depression and almost half of patients suffer from it It is an important source of burden affecting both personal and occupational life Despite its high prevalence and negative consequences no pharmacological or non-pharmacological treatments exist the underlying mechanisms of apathy being poorly understood The main aim of the present study is to advance in our knowledge of cognitive and neural mechanisms of apathy by using a multidimensional model of apathy distinguishing three forms executive emotional and auto-activationinitiative
the investigators hypothesize independently of the pathology schizophrenia and depression the existence of different cognitive deficits underlying each of the 3 subforms of apathy Indeed according to the predictions of Levy and Dubois model 2006 executive disorders underlie the cognitive form of apathy It may be related to lesions of the dorsolateral prefrontal cortex and the cognitive territory of the basal ganglia Emotional apathy could be due to motivational disorder Dysfunctions or lesions in the orbital and medial prefrontal cortex and limbic territories of the basal ganglia may underlie this Finally the initiative form may be a mixed form with both motivational and executive difficulties Lesions or dysfunctions may affect both the cognitive and limbic territories of the basal ganglia or the anterior cingulate cortex
the investigators hypothesize independently of the pathology schizophrenia and depression the existence of different cognitive deficits underlying each of the 3 subforms of apathy Indeed according to the predictions of Levy and Dubois model 2006 executive disorders underlie the cognitive form of apathy It may be related to lesions of the dorsolateral prefrontal cortex and the cognitive territory of the basal ganglia Emotional apathy could be due to motivational disorder Dysfunctions or lesions in the orbital and medial prefrontal cortex and limbic territories of the basal ganglia may underlie this Finally the initiative form may be a mixed form with both motivational and executive difficulties Lesions or dysfunctions may affect both the cognitive and limbic territories of the basal ganglia or the anterior cingulate cortex
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None