Ignite Creation Date:
2024-05-06 @ 3:47 PM
Last Modification Date:
2024-10-26 @ 1:57 PM
Study NCT ID:
NCT04758455
Status:
UNKNOWN
Last Update Posted:
2021-02-17
First Post:
2021-02-14
Brief Title:
The Use of Immunohistochemical Staining for the Prediction of Wilms Tumour Progression and Recurrence
Sponsor:
Mansoura University
Organization:
Mansoura University
Study Overview
Official Title:
P53 Ki67 and Cyclin A Immunohistochemical Staining as Predictors for Wilms Tumour Aggressiveness and Recurrence
Status:
UNKNOWN
Status Verified Date:
2021-02
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Wilms tumour staging and grading are used to give an idea about the prognosis Advanced staging diffuse anaplasia predominant blastemal elements and lymph node invasion are indicators of poor prognosis In spite of using the previously mentioned parameters some tumours which were considered of low risk did not respond to therapy and eventually resulted in mortality In contrast other tumours assumed to be of poor prognosis responded dramatically to treatment
In light of the above it is crucial to search for predictors of Wilms tumour prognosis other than tumour staging and grading Many immunohistochemical IHC stains have been studied as prognostic markers for nephroblastoma in literature
In light of the above it is crucial to search for predictors of Wilms tumour prognosis other than tumour staging and grading Many immunohistochemical IHC stains have been studied as prognostic markers for nephroblastoma in literature
Detailed Description:
P53 is a tumour suppressor gene and its mutation is identified in various types of human cancer P53 protein accumulation in certain tumours is associated with tumour aggressiveness The role of P53 expression in Wilms tumour is not clear however most studies confirmed its correlation with advanced stages and anaplasia
Ki67 is a nuclear antigen related to cell proliferation and high Ki67 proliferation index PI is accompanied by tumour aggressiveness distant metastasis and death Advanced stages and clinical progression of WT were found to be associated with high Ki67 PI On the other hand some authors concluded that it may not be a dependable prognostic marker
The cyclin-dependent kinases CDKs have a role in transitions between cell cycle phases with the need of cyclins association for their activity IHC assessment of cell cycle proteins has a diagnostic use in histopathology Correlation between poor prognosis and overexpression of cyclin A was confirmed in different entities of human cancer such as medulloblastoma and ovarian carcinoma A recent study deduced that cyclin A overexpression may be associated with the poor prognosis of WT
Ki67 is a nuclear antigen related to cell proliferation and high Ki67 proliferation index PI is accompanied by tumour aggressiveness distant metastasis and death Advanced stages and clinical progression of WT were found to be associated with high Ki67 PI On the other hand some authors concluded that it may not be a dependable prognostic marker
The cyclin-dependent kinases CDKs have a role in transitions between cell cycle phases with the need of cyclins association for their activity IHC assessment of cell cycle proteins has a diagnostic use in histopathology Correlation between poor prognosis and overexpression of cyclin A was confirmed in different entities of human cancer such as medulloblastoma and ovarian carcinoma A recent study deduced that cyclin A overexpression may be associated with the poor prognosis of WT
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None