Ignite Creation Date:
2024-05-06 @ 3:47 PM
Last Modification Date:
2024-10-26 @ 1:56 PM
Study NCT ID:
NCT04752111
Status:
COMPLETED
Last Update Posted:
2021-10-01
First Post:
2021-01-28
Brief Title:
Dose Esmolol Infusion Have an Adjuvant Effect to TAP Block for Pain Control in Laparoscopic Cholecystectomy
Sponsor:
Benha University
Organization:
Benha University
Study Overview
Official Title:
Dose Esmolol Infusion Have an Adjuvant Effect to Transversus Abdominis Plane Block for Pain Control in Laparoscopic Cholecystectomy A Randomized Controlled Double-blind Trial
Status:
COMPLETED
Status Verified Date:
2021-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pain after laparoscopy differs considerably from that seen after laparotomy Laparotomy results mainly in parietal pain abdominal wall where as Pain in laparoscopy results from stretching of the intra-abdominal cavity peritoneal inflammation and diaphragmatic irritation caused by residual carbon-dioxide in the peritoneal cavity The transverse abdominis plane TAP block is a peripheral nerve block designed to anesthetize the nerves supplying the anterior abdominal wall T6 to L1 While esmolol is an ultra-short acting intravenous β-blocker having a rapid onset and offset effect It provides an unprecedented level of tolerability and safety in the perioperative setting When used as an adjunct it has been shown to improve the postoperative recovery by reducing postoperative pain intensity and intraoperative anesthetic and opioid requirements and preventing opioid-induced hyperalgesia The mechanism of this synergistic effect is uncertain but both pharmacokinetic and pharmacodynamics interactions with anesthetic drugs have been proposed
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None