Ignite Creation Date:
2024-05-06 @ 3:47 PM
Last Modification Date:
2024-10-26 @ 1:57 PM
Study NCT ID:
NCT04754880
Status:
COMPLETED
Last Update Posted:
2021-02-15
First Post:
2021-01-30
Brief Title:
Coronary Chronic Total Occlusion and Oxidative Balance
Sponsor:
Kahramanmaras Sutcu Imam University
Organization:
Kahramanmaras Sutcu Imam University
Study Overview
Official Title:
The Relationship Between Oxidative Stress Markers and Presence of Chronic Total Occlusion in Coronary Artery Disease
Status:
COMPLETED
Status Verified Date:
2021-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The presence of chronic blockage of coronary arteries which we may accept as the terminal point of atherosclerotic coronary artery disease is closely associated with a poor prognosis The Discovery of markers that may distinguish patients with a high risk of chronic total occlusion development among patients monitored with the diagnosis of stable coronary artery disease may be important for being able to reduce the increased mortality and morbidity rates
Oxidative stress status may be one of the markers that play a role in andor show the development of chronic total occlusion It was reported that it has a role in the progression erosion and instability of atherosclerotic plaques in coronary arteries To the best of our knowledge the relationship between chronic total occlusion development and oxidative stress status in stable coronary artery disease has not been studied
This study investigated the relationships in the oxidative stress status evaluated over TAS TOS OSI ThiolDisulfide Homeostasis and antioxidative vitamin levels and possible differences in patients with noncritical coronary artery disease and those with chronic total occlusion
Oxidative stress status may be one of the markers that play a role in andor show the development of chronic total occlusion It was reported that it has a role in the progression erosion and instability of atherosclerotic plaques in coronary arteries To the best of our knowledge the relationship between chronic total occlusion development and oxidative stress status in stable coronary artery disease has not been studied
This study investigated the relationships in the oxidative stress status evaluated over TAS TOS OSI ThiolDisulfide Homeostasis and antioxidative vitamin levels and possible differences in patients with noncritical coronary artery disease and those with chronic total occlusion
Detailed Description:
Chronic total occlusion CTO is defined as the complete blockage of the coronary artery characterized by a TIMI 0 flow present for at least 3 months The presence of chronic blockage of coronary arteries which we may accept as the terminal point of atherosclerotic coronary artery disease is closely associated with a poor prognosis In coronary angiography tests conducted due to stable angina pectoris it was observed that the incidence of chronic total occlusion varied in the range of 15-30 Moreover its actual incidence in society is unknown as it is generally asymptomatic The Discovery of markers that may distinguish patients with a high risk of chronic total occlusion development among patients monitored with the diagnosis of stable coronary artery disease may be important for being able to reduce the increased mortality and morbidity rates
Oxidative stress status may be one of the markers that play a role in andor show the development of chronic total occlusion Reactive oxygen species which show an increase in the case of oxidative stress emerging by increased production of oxidants on the cellular level or a reduced antioxidant system result in disorders on the tissue and organ levels as a result of the damages they induce on DNA protein and lipid structures It was reported that it has a role in the progression erosion and instability of atherosclerotic plaques in coronary arteries Furthermore the relationship between oxidative stress and the progression of atherosclerosis in coronary arteries has been usually studied in acute coronary syndrome patients To the best of our knowledge the relationship between chronic total occlusion development and oxidative stress status in stable coronary artery disease has not been studied
This study investigated the relationships in the oxidative stress status evaluated over TAS TOS OSI ThiolDisulfide Homeostasis and antioxidative vitamin levels and possible differences in patients with noncritical coronary artery disease and those with chronic total occlusion
Oxidative stress status may be one of the markers that play a role in andor show the development of chronic total occlusion Reactive oxygen species which show an increase in the case of oxidative stress emerging by increased production of oxidants on the cellular level or a reduced antioxidant system result in disorders on the tissue and organ levels as a result of the damages they induce on DNA protein and lipid structures It was reported that it has a role in the progression erosion and instability of atherosclerotic plaques in coronary arteries Furthermore the relationship between oxidative stress and the progression of atherosclerosis in coronary arteries has been usually studied in acute coronary syndrome patients To the best of our knowledge the relationship between chronic total occlusion development and oxidative stress status in stable coronary artery disease has not been studied
This study investigated the relationships in the oxidative stress status evaluated over TAS TOS OSI ThiolDisulfide Homeostasis and antioxidative vitamin levels and possible differences in patients with noncritical coronary artery disease and those with chronic total occlusion
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None