Ignite Creation Date:
2024-05-06 @ 3:47 PM
Last Modification Date:
2024-10-26 @ 1:56 PM
Study NCT ID:
NCT04753762
Status:
COMPLETED
Last Update Posted:
2023-05-08
First Post:
2021-01-26
Brief Title:
Multimodal IMAgery Characterization of Cardiac Damage and Severity After COVID-19 Infection
Sponsor:
Central Hospital Nancy France
Organization:
Central Hospital Nancy France
Study Overview
Official Title:
Multimodal IMAgery Echocardiography and Cardiac MRI Characterization of Cardiac Damage and Severity After COVID-19 Infection
Status:
COMPLETED
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
IMACovid
Brief Summary:
Coronavirus Disease 2019 COVID-19 is an infection caused by Severe Acute Respiratory Syndrome Coronavirus SARS-CoV-2 which affects multiple organ system particularly the lung and heart Indeed SARS CoV-2 has various cardiac manifestations which are associated with higher mortality and morbidity Cardiac involvement based on elevated levels of myocardial enzymes have been described in 20 to 30 of COVID-19 infection However the physiopathological mechanisms of myocardial injury remains unclear Main hypothesis include inflammation and cytokine storm hypercoagulability and vascular thrombosis inflammation or stress leading to coronary plaque rupture type I myocardial infarction supply-demand mismatch and hypoxemia resulting in myocardial damage type II myocardial infarction
Two patterns can be identified ischemic or non-ischemic pattern including myocarditis stress induced cardiomyopathy thrombo-embolic disease However the consequences of myocardial damage after confirmed COVID-19 infection are unknown at medium to long term prognosis
Data are needed to identify myocardial damage and to guide effective therapies and follow-up use of ACE inhibitor beta-blockers steroids In this study the investigators proposed to collect multimodal cardiac imaging including MRI Magnetic Resonance Imaging and TTE Transthoracic echocardiogram in order to identify and characterize cardiac injury as ischemic or non-ischemic pattern to better assess risk stratification and to guide effective therapies if necessary
Two patterns can be identified ischemic or non-ischemic pattern including myocarditis stress induced cardiomyopathy thrombo-embolic disease However the consequences of myocardial damage after confirmed COVID-19 infection are unknown at medium to long term prognosis
Data are needed to identify myocardial damage and to guide effective therapies and follow-up use of ACE inhibitor beta-blockers steroids In this study the investigators proposed to collect multimodal cardiac imaging including MRI Magnetic Resonance Imaging and TTE Transthoracic echocardiogram in order to identify and characterize cardiac injury as ischemic or non-ischemic pattern to better assess risk stratification and to guide effective therapies if necessary
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None