Ignite Creation Date:
2024-05-06 @ 3:46 PM
Last Modification Date:
2024-10-26 @ 1:56 PM
Study NCT ID:
NCT04744519
Status:
COMPLETED
Last Update Posted:
2021-02-09
First Post:
2021-01-29
Brief Title:
hCG Concentration in Peripheral Maternal Blood After Embryo Transfer Ongoing Pregnancy Rates and Morphokinetics
Sponsor:
IVI Vigo
Organization:
IVI Vigo
Study Overview
Official Title:
hCG Concentration in Peripheral Maternal Blood After Embryo Transfer Ongoing Pregnancy
Status:
COMPLETED
Status Verified Date:
2021-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
hCG is a hormone produced very early by the embryo but not by the oocyte It has a pivotal role in the trophoblast differentiation and embryo implantation as well as the corpus luteum support In spite of its well-known role the literature about it is scarce
The aim of this retrospective study is to evaluate the relationship between the hCG concentration in peripheral maternal blood measured 11 days after embryo transfer embryo morphokinetics pattern and the abortion and ongoing pregnancy rates
We will study patients having transference of blastocyst cultured in time lapse monitored incubators and will check all the morphokinetics parameters with the IVI database
The aim of this retrospective study is to evaluate the relationship between the hCG concentration in peripheral maternal blood measured 11 days after embryo transfer embryo morphokinetics pattern and the abortion and ongoing pregnancy rates
We will study patients having transference of blastocyst cultured in time lapse monitored incubators and will check all the morphokinetics parameters with the IVI database
Detailed Description:
Human chorionic gonadotrophin is a two subunits alpha and beta glycoprotein hormone secreted by blastocyst trophoblastic cells
It plays a role in progesterone secretion by corpus luteum endometrium invasion and fusion by trophoectoderm angiogenesis and induction of trophoblast differentiation Shortly after embryo implantation trophoblastic hCG is detectable in maternal blood and its concetration depends on the number and functionality of trophoectoderm cells Therefore hCG concentration in maternal blood is measured as an early pregnancy marker
However hCG concentration in several women showed high variability and embryo implantation also depends on endometrial receptivity what means that in early stages everything affecting endometrial receptivity may affect hCG concentration
Early high hCG concentration has been related with higher pregnancy rate and it has been proposed that hCG concentration may be related to the time of embryo implantation and the viable trophoectoderm cell number
It plays a role in progesterone secretion by corpus luteum endometrium invasion and fusion by trophoectoderm angiogenesis and induction of trophoblast differentiation Shortly after embryo implantation trophoblastic hCG is detectable in maternal blood and its concetration depends on the number and functionality of trophoectoderm cells Therefore hCG concentration in maternal blood is measured as an early pregnancy marker
However hCG concentration in several women showed high variability and embryo implantation also depends on endometrial receptivity what means that in early stages everything affecting endometrial receptivity may affect hCG concentration
Early high hCG concentration has been related with higher pregnancy rate and it has been proposed that hCG concentration may be related to the time of embryo implantation and the viable trophoectoderm cell number
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None