Ignite Creation Date:
2024-05-06 @ 3:45 PM
Last Modification Date:
2024-10-26 @ 1:56 PM
Study NCT ID:
NCT04740528
Status:
COMPLETED
Last Update Posted:
2021-03-02
First Post:
2021-02-01
Brief Title:
Preference of Protein Intake and FTO rs1558902 Gene Polymorphism Among Women Obese
Sponsor:
Universitas Diponegoro
Organization:
Universitas Diponegoro
Study Overview
Official Title:
Department of Nutrition Science Medical Faculty Universitas Diponegoro Semarang Indonesia
Status:
COMPLETED
Status Verified Date:
2021-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The concept personalized gene-based nutrition combines genetic information with specific dietary intake that is crucial in managing obesity Obesity experienced by adult women is generally caused by inapproriate diet and sedentary lifestyle Variations in the fat mass and obesity-related gene FTO has been linked with susceptibility to obesity but diet seems to change the relationship A single nucleotide polymorphism SNP in the fat mass and obesity-associated gene FTO is a potent predictor of human obesity Higher protein diets were more appropriate than standard protein diets and frequently recommended as a weight loss plan as it prevents the loss of lean tissue mass Nevertheless high intakes of proteins may adversely affect metabolic functions Multi studies have explored associated FTO polymorphisms with obesity in different populations However the contribution of the FTO common variants to obesity is controversial in Asian people some studies showed rs1558902 was statistically associated with BMI but other results reported FTO gene is not statistically associated with obesity Given the diversity of Asian populations the investigators generated a hypothesis whether relations between preference protein intake and FTO rs1558902 gene polymorphism exist in selected Indonesian obesity women
Detailed Description:
The sample size was calculated based on the difference in the proportion of variation of the gene FTO rs1558902 allele A between obese participants which previous study estimated to be approximately 6 for populations from Malaysia Using a power of 80 and a level of significance of 5 the investigators required 100 obese participants
BMI and body fat which were assessed by SECA body analyzer SECA 201 Blood samples were collected after a 12-h minimum fast by Prodia Laboratory for DNA isolation and biochemical analysis
BMI and body fat which were assessed by SECA body analyzer SECA 201 Blood samples were collected after a 12-h minimum fast by Prodia Laboratory for DNA isolation and biochemical analysis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None