Viewing Study NCT04748796



Ignite Creation Date: 2024-05-06 @ 3:45 PM
Last Modification Date: 2024-10-26 @ 1:56 PM
Study NCT ID: NCT04748796
Status: RECRUITING
Last Update Posted: 2023-02-10
First Post: 2021-01-27

Brief Title: Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility
Sponsor: Centre Hospitalier Universitaire Amiens
Organization: Centre Hospitalier Universitaire Amiens

Study Overview

Official Title: Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility an Open Label Prospective Randomized Study
Status: RECRUITING
Status Verified Date: 2023-02
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: HyperBetashock
Brief Summary: Several data emphasize the relation between tachycardia 90min and high mortality during septic shock The investigators previously demonstrated the high mortality associated with hypercontractility tachycardia and the presence of a left ventricular obstruction A severe hypovolemia a hyper adrenergic stimulation or a severe vasoplegia can all explain this relation between tachycardia hypercontractility and the mortality during septic shock

Landiolol is another short-term acting beta-blocker with a half-life of 4 minutes without any beta 2 activity or membrane stabilizing effect The landiolol has been used in critically ill patients to control supraventricular tachycardia but not in this context of tachycardia and septic shock The investigators hypothesize that landiolol by reducing the heart rate may improve the survival of patients treated for a septic shock and presenting with an hypercontractility state
Detailed Description: None

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: False
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None