Ignite Creation Date:
2024-05-05 @ 5:18 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00422136
Status:
COMPLETED
Last Update Posted:
2017-11-14
First Post:
2007-01-12
Brief Title:
Genetics of Middle Ear Disease
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Genetic Epidemiology of Otitis Media
Status:
COMPLETED
Status Verified Date:
2017-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this study is to identify the genes that contribute to susceptibility to recurrentpersistent middle ear disease Five hundred families with at least 2 children who have undergone tympanostomy tube insertion will be enrolled A blood sample will be obtained from the children who had tubes and any available parent at least 1 as well as any siblings without significant histories of middle ear disease
Detailed Description:
Using the twin study approach the investigators demonstrated that time with middle ear effusion MEE number of episodes of MEE and numbers of episodes of acute otitis media AOM have a strong genetic component The point estimate of heritability of time with MEE was 073 While there is significant evidence that susceptibility to recurrentpersistent OM is largely genetically determined the specific genes which confer susceptibility are unknown The overall research strategy to identify genes underlying OM is to apply a three-stage study design that will allow the investigators to balance cost efficiency with statistical power Five hundred evaluable pairs of siblings with a history of tympanostomy tube insertion affected their parents and available non-affected full siblings will be recruited A blood sample will be obtained from each subject for genotyping
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DC005630 | NIH | None | httpsreporternihgovquickSearchR01DC005630 |