Ignite Creation Date:
2024-05-06 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 1:55 PM
Study NCT ID:
NCT04732299
Status:
UNKNOWN
Last Update Posted:
2021-08-19
First Post:
2021-01-28
Brief Title:
Staging and Prognosis of Deep Venous Thrombosis of Lower Extremities
Sponsor:
First Affiliated Hospital Xian Jiaotong University
Organization:
First Affiliated Hospital Xian Jiaotong University
Study Overview
Official Title:
Staging Diagnosis and Prognosis of Lower Extremity Deep Venous Thrombosis Based on Magnetic Resonance Imaging a Prospective Study
Status:
UNKNOWN
Status Verified Date:
2021-08
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Deep venous thrombosis DVT is a venous reflux disorder caused by abnormal coagulation of blood in the deep vein which usually occurs in the lower extremities After thrombosis venous valve function is often destroyed causing lower limb swelling ulcers and other congestive diseases affecting the quality of life of patients thrombus shedding is also easy to cause pulmonary embolism serious cases can lead to sudden death Therefore the accurate diagnosis and curative effect evaluation of DVT are of great significance to the prognosis of patients At present the treatment of DVT includes systematic thrombolysis and catheter contact thrombolysis among which oral drug thrombolysis has certain advantages in clinical application However in the process of thrombosis the composition of thrombus is different in different periods thus defining the staging of thrombus plays an important role in the decision-making of drug treatment In view of the high resolution of magnetic resonance imaging of soft tissue thrombus can be directly imaged Therefore this project will take the staging diagnosis of deep venous thrombosis as the starting point Through the development of magnetic resonance imaging this paper tries to solve the problem of evaluating the therapeutic effect of deep venous thrombosis in clinic
Detailed Description:
Deep venous thrombosis DVT is a venous reflux disorder caused by abnormal blood coagulation in the deep vein which usually occurs in the lower extremities DVT is common in patients with limb immobilization such as after major orthopedic surgery severe trauma tumor coma or long-term bedridden patients After thrombosis venous valve function is often destroyed causing lower limb swelling ulcers and other congestive diseases affecting the quality of life of patients thrombus shedding is also easy to cause pulmonary embolism serious cases can lead to sudden death
In the process of thrombosis the components of thrombus are different in different stages in the acute stage of thrombosis the consumption of blood fibroses is less mainly in the thrombolytic therapy of activating plasminogen in the subacute and chronic phase of thrombosis the consumption of fibrinolytic enzyme is more anticoagulant therapy is needed to prolong the clotting time Therefore defining the staging of thrombus is the key to make a reasonable treatment plan and improve the therapeutic effect of DVT The guidelines recommend that for patients with moderate or high likelihood of DVT if two consecutive ultrasound examinations are negative further X-ray venography CT venography or magnetic resonance venous thrombosis direct imaging are recommended Among them magnetic resonance thrombus direct imaging depends on the content of methemoglobin in the body and will not produce radiation to the human body it can not only accurately judge the thrombus in the pelvic and inferior vena cava but also show the details of the changes in the vein wall or lumen Therefore magnetic resonance thrombus direct imaging has a certain potential in the differential diagnosis of acute subacute and old thrombus In this study we will use magnetic resonance thrombus direct imaging to stage and judge the efficacy of drug treatment in order to provide help for clinic
In the process of thrombosis the components of thrombus are different in different stages in the acute stage of thrombosis the consumption of blood fibroses is less mainly in the thrombolytic therapy of activating plasminogen in the subacute and chronic phase of thrombosis the consumption of fibrinolytic enzyme is more anticoagulant therapy is needed to prolong the clotting time Therefore defining the staging of thrombus is the key to make a reasonable treatment plan and improve the therapeutic effect of DVT The guidelines recommend that for patients with moderate or high likelihood of DVT if two consecutive ultrasound examinations are negative further X-ray venography CT venography or magnetic resonance venous thrombosis direct imaging are recommended Among them magnetic resonance thrombus direct imaging depends on the content of methemoglobin in the body and will not produce radiation to the human body it can not only accurately judge the thrombus in the pelvic and inferior vena cava but also show the details of the changes in the vein wall or lumen Therefore magnetic resonance thrombus direct imaging has a certain potential in the differential diagnosis of acute subacute and old thrombus In this study we will use magnetic resonance thrombus direct imaging to stage and judge the efficacy of drug treatment in order to provide help for clinic
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None