Ignite Creation Date:
2024-05-06 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 1:54 PM
Study NCT ID:
NCT04723433
Status:
COMPLETED
Last Update Posted:
2021-09-14
First Post:
2021-01-21
Brief Title:
Recovery of Ventilation After Anesthesia for Laparoscopic Nephrectomy
Sponsor:
Stanford University
Organization:
Stanford University
Study Overview
Official Title:
Recovery of Ventilation After General Anesthesia for Robotic-assisted Laparoscopic Nephrectomy The Effect of Conservative Versus Liberal Oxygen Supplementation - A Feasibility Study
Status:
COMPLETED
Status Verified Date:
2021-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this randomized controlled feasibility investigation is to characterize pharmacologically induced ventilatory depression after anesthesia and examine how is affected by the amount of supplemental oxygen patients are receiving in the immediate postoperative period
Detailed Description:
The purpose of this study is characterize pharmacologically induced ventilatory depression after anesthesia and examine how is affected by the amount of supplemental oxygen patients are receiving in the immediate postoperative period since hyperoxemia ie higher than necessary partial pressure of oxygen in the arterial blood has been associated with ventilatory depression via suppression of the hypoxic ventilatory drive
In this feasibility randomized controlled trial the investigators plan to estimate and compare the cumulative segment of time during which the transcutaneous partial pressure of carbon dioxide will exceed an upper limit of 45 mmHg ie TcPCO2 45 mmHg for the 90-min-long post-anesthesia period between the conventional titrated to an oxygen saturation 96 and the conservative titrated to O2 saturation 90 -94 O2 supplementation interventions
Hypothesis Conservative use of O2 titrated to an SpO2 90 - 94 will be associated with less hypoventilation ie less time spent with an TcPCO2 45 mmHg during recovery from general anesthesia compared to liberal O2 supplementation SpO2 96
In this feasibility randomized controlled trial the investigators plan to estimate and compare the cumulative segment of time during which the transcutaneous partial pressure of carbon dioxide will exceed an upper limit of 45 mmHg ie TcPCO2 45 mmHg for the 90-min-long post-anesthesia period between the conventional titrated to an oxygen saturation 96 and the conservative titrated to O2 saturation 90 -94 O2 supplementation interventions
Hypothesis Conservative use of O2 titrated to an SpO2 90 - 94 will be associated with less hypoventilation ie less time spent with an TcPCO2 45 mmHg during recovery from general anesthesia compared to liberal O2 supplementation SpO2 96
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None