Ignite Creation Date:
2024-05-06 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 1:55 PM
Study NCT ID:
NCT04729855
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-04-16
First Post:
2021-01-24
Brief Title:
Association of Autophagy-related Genes LncRNA and SNPs With Colorectal Cancer in Egyptian Population
Sponsor:
Esraa HassanMD
Organization:
Assiut University
Study Overview
Official Title:
Association of Autophagy-related Genes LncRNA and SNPs With Colorectal Cancer in Egyptian Population
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 Determination of expression level of HOTTIP and EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1
2 Investigation of the SNP HOTTIP rs1859168 and its association with CRC susceptibility
3 Correlation of the expression of these genes with various stages of CRC to determine the prognostic value of each of them
2 Investigation of the SNP HOTTIP rs1859168 and its association with CRC susceptibility
3 Correlation of the expression of these genes with various stages of CRC to determine the prognostic value of each of them
Detailed Description:
Colorectal cancer CRC is a common digestive tract tumor 1It is the third leading cause of death in the world Overall 5-year survival rate is less than 40 and the occurrence is rising 2 However the prognosis and therapy have not been significantly improved Therefore a proper selection of patients for aggressive treatment is necessary new therapeutic and prognostic strategies are urgently needed 3
Autophagy is a pathway for self-digestion in which unwanted cytoplasmic components are recycled 4In normal conditions autophagy is essential for cellular homeostasis 5 Autophagy has dual roles in cancer cells stimulation or suppression with effects on progression and oncogenesis 6Recent research established that autophagy is important target for controlling cancer depending on stage and type of tumor 7Diverse molecular mechanisms contribute to cancer cells resistance to treatment 8Among these mechanisms autophagy appears to be critical 9
EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 is encoded by EIF4EBP1 geneIt acts as an effector in mTOR mammilian target of rapamycin pathway which on activation EIF4EBP1 is phosphorylated promoting cell proliferation 10 Studies have suggested that EIF4EBP1 promotes carcinogenesis as in hepatocellular carcinoma However its role in CRC have not been elucidated 10
Long non-coding RNAs lncRNAs are group of RNA 200 nucleotides in length 11 Expression of lncRNAs has been discovered in multiple tumors acting as oncogenes HOXAhydrogenase transcriptional regulatory protein transcript at the distal tip HOTTIP has received attention latelyIt is up-regulated in CRC tissue regulating genes via epigenetic modification Therefore it might be a candidate for cancerization and therapy of CRC 12
Expression of lncRNAs could be affected by single nucleotide polymorphisms SNPs the most common genetic variation in human genomes13 rs1859168 was reported as a potential functional polymorphism on HOTTIP that alters its expression level 14 Also it was recently reported that HOTTIP enhances interleukin 6 expression which potentiates immune escape of cancer cells 15
Autophagy is a pathway for self-digestion in which unwanted cytoplasmic components are recycled 4In normal conditions autophagy is essential for cellular homeostasis 5 Autophagy has dual roles in cancer cells stimulation or suppression with effects on progression and oncogenesis 6Recent research established that autophagy is important target for controlling cancer depending on stage and type of tumor 7Diverse molecular mechanisms contribute to cancer cells resistance to treatment 8Among these mechanisms autophagy appears to be critical 9
EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 is encoded by EIF4EBP1 geneIt acts as an effector in mTOR mammilian target of rapamycin pathway which on activation EIF4EBP1 is phosphorylated promoting cell proliferation 10 Studies have suggested that EIF4EBP1 promotes carcinogenesis as in hepatocellular carcinoma However its role in CRC have not been elucidated 10
Long non-coding RNAs lncRNAs are group of RNA 200 nucleotides in length 11 Expression of lncRNAs has been discovered in multiple tumors acting as oncogenes HOXAhydrogenase transcriptional regulatory protein transcript at the distal tip HOTTIP has received attention latelyIt is up-regulated in CRC tissue regulating genes via epigenetic modification Therefore it might be a candidate for cancerization and therapy of CRC 12
Expression of lncRNAs could be affected by single nucleotide polymorphisms SNPs the most common genetic variation in human genomes13 rs1859168 was reported as a potential functional polymorphism on HOTTIP that alters its expression level 14 Also it was recently reported that HOTTIP enhances interleukin 6 expression which potentiates immune escape of cancer cells 15
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None