Viewing Study NCT04723732



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Last Modification Date: 2024-10-26 @ 1:55 PM
Study NCT ID: NCT04723732
Status: COMPLETED
Last Update Posted: 2021-01-26
First Post: 2020-11-09

Brief Title: Antiplaque Antigingivitis and Anti-inflammatory Effects of Myrrh Mouthwash
Sponsor: King Abdulaziz University
Organization: King Abdulaziz University

Study Overview

Official Title: A Clinical Study Comparing the Antiplaque Antigingivitis and Anti-inflammatory Effects of Myrrh Mouthwash With Chlorhexidine Mouthwash in a 14-Day Experimental Gingivitis Model
Status: COMPLETED
Status Verified Date: 2021-01
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: Myrrh-based mouthwash has the potential to be a suitable alternative to the gold standard chlorhexidine mouthwash for dental plaque and gingivitis reduction To date however little research has been carried out to determine its true clinical significance on periodontal health The purpose of this study is to evaluate and compare the efficacy of 1 myrrh mouthwash with commercially available 02 chlorhexidine mouthwash in terms of plaque and gingivitis reduction and inflammatory mediator interleukin-1β inhibition
Detailed Description: This will be a single-center triple-blinded randomized three-arm parallel controlled trial in periodontally healthy adult volunteers no clinical attachment loss and bleeding on probing 10 We will include all eligible patients seeking dental treatment at the center after gaining a written informed consent After the initial dental screening and a session of professional teeth cleaning procedures participants will be instructed to refrain from regular oral hygiene practices for 2 weeks to develop experimental gingivitis Participants will then be randomly allocated to one of the three treatment groups 111 using a simple randomization method ie computer-generated random numbers They will be instructed to continue refrain from regular oral hygiene practices and use 10 ml of the assigned mouthwash twice daily for 1 minute Treatment effect will be evaluated by comparing the baseline day 0 and post-intervention day 14 values of all clinical parameters modified gingival index plaque index proinflammatory interleukin-1β biomarker and Gingival Bleeding Index

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: False
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None