Ignite Creation Date:
2024-05-05 @ 5:18 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00423956
Status:
UNKNOWN
Last Update Posted:
2013-01-23
First Post:
2007-01-16
Brief Title:
Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound
Sponsor:
University of Alberta Graduate Orthodontic Program
Organization:
University of Alberta Graduate Orthodontic Program
Study Overview
Official Title:
Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound in Human Subjects
Status:
UNKNOWN
Status Verified Date:
2013-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Tooth-root resorption also known as shortening or erosionTRR is one of the adverse outcomes of dental trauma orthodontic tooth movement and dental replantationtransplantation Orthodontically induced inflammatory root resorption OIIRR is somewhat different from other types of TRR The treatment protocol of teeth diagnosed with severe OIIRR or other forms of TRR always involves root canal treatment or extraction of these teeth in severe cases and prosthetic replacement Sometimes teeth with minor TRR may stay for an extended period of time with compromised bite functions Although several trials have been proposed to minimize or prevent TRR or OIIRR none is capable of being used in clinical situation to treat TRR or OIIRR in humans except for Low Intensity Pulsed Ultrasound LIPUS However research examining the use of LIPUS to treat OIIRR has been limited to simple orthodontic tooth tipping In reality tooth movement is a combination of different types of tooth movements namely tipping bodily rotational torque intrusion and extrusion tooth movements However the literature have pointed out that torque tooth movement especially when the root apices are torques against cortical plates of bone produces the most dramatic type of tooth root resorption with poor prognosis Our long-term goal is to develop a standard protocol for treating severe tooth root resorption with poor prognosis in humans regardless of origin Our preliminary data demonstrates that LIPUS can produce healing of OIIRR in humans after simple tipping movement this was confirmed by an in-vitro study on isolated cementoblasts The objective of the present proposal is to evaluate the effect of different treatment protocols of LIPUS on the healing process of orthodontically induced tooth-root resorption due to torque Complextype of tooth movement in humans
The study Hypotheses are I LIPUS treatment for 20 minutes per day for 4 weeks will be effective in repairing OIIRR due to torque tooth movement
II The stimulatory effect of LIPUS to repair OIIRR due to torque tooth movement than LIPUS treatment is dose and time dependent
The study Hypotheses are I LIPUS treatment for 20 minutes per day for 4 weeks will be effective in repairing OIIRR due to torque tooth movement
II The stimulatory effect of LIPUS to repair OIIRR due to torque tooth movement than LIPUS treatment is dose and time dependent
Detailed Description:
For each patient specially designed springs will be used to achieve standard torque orthodontic tooth movement of the first premolars to induce OIIRR The first molars will be stabilized using a special appliance to help movement of the premolars This type of appliance design has been used for many years in similar clinical trials by many researchers and has received wide acceptability without reported problems to the teeth during the experimental period Ultrasound will be applied for twenty minutes per day starting the day the springs are activated for four weeks using an ultrasound device Exogen Inc West Caldwell NJ USA Only the first premolar will be receiving ultrasound The patients will be instructed on how to have the ultrasound transducer The non LIPUS treated premolars will be receiving sham transducers A visual analogue scale will be provided to the patients to record any pain or discomfort that the patient might experience during or after application of ultrasound It is expected that there will be no evidence of any deleterious effect on the intervening soft tissue as we did not informed with any discomfort experienced by the patients in our preliminary study After four or eight weeks of LIPUS treatment the springs will be removed and the first premolars will be extracted using a non-traumatic technique The extracted teeth will be fixed and studied by μ-CT then they will be processed to be analyzed histomorphometrically
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None