Ignite Creation Date:
2024-05-06 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 1:54 PM
Study NCT ID:
NCT04710329
Status:
COMPLETED
Last Update Posted:
2021-02-15
First Post:
2021-01-13
Brief Title:
High-Dose Vitamin C Treatment in Critically Ill COVID-19 Patients
Sponsor:
Sisli Hamidiye Etfal Training and Research Hospital
Organization:
Sisli Hamidiye Etfal Training and Research Hospital
Study Overview
Official Title:
High-Dose Vitamin C Treatment in Critically Ill COVID-19 Patients A Retrospective Cohort Study
Status:
COMPLETED
Status Verified Date:
2021-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute respiratory failure due to COVİD-19 pneumonia has poor prognosis and high mortality Both the lack of an effective antiviral treatment and the low level evidence of the recommendations presented in the guidelines on other treatment methods have highlighted supportive treatments Studies suggest that high-dose vitamin C treatment reduces mortality in patients with sepsis and ARDS and may also be beneficial in COVİD-19 disease In the study the investigator aimed to determine the effect of Vitamin C on short-term mortality and length of intensive care stay in COVID-19 patients
Detailed Description:
SARS-CoV-2 causes tissue damage in the endothelium and epithelium increased vascular permeability and increased plasma levels of IL-6 IL-2 IL-7 IL-10 causing interstitial fibrosis in the lung is considered Considering these factors in pathogenesis a picture with high mortality from acute respiratory failure to severe ARDS emerges in critically ill COVID-19 patients However despite numerous studies an effective antiviral treatment has not yet been found in COVID-19 disease The low level of evidence for the recommendations presented in the guidelines on both treatment and mechanical ventilation has brought supportive treatments to the agenda Recently many articles have been published on the potential effects of anti-inflammatory and antioxidant treatments such as high-dose vitamin C vitamin D zinc and ozone therapy In particular high-dose intravenous vitamin C treatment is inexpensive easily accessible and it reduces mortality in patients with sepsis and ARDS in studies suggesting that it may be beneficial in COVID-19 disease this is a retrospective cohort study The main goal of the study to compare patients who did not receive high-dose vitamin C treatment in the first period of the epidemic and those who received treatment in the next period the investigator aimed to determine the effect of Vitamin C on short-term mortality and length of stay in intensive care in critically ill COVID-19 patients All patients data on age gender body mass index comorbidities diabetes mellitus hypertension coronary artery disease chronic obstructive pulmonary disease other PaO2 FiO2 ratios SOFA scores ferritin C-Reactive Protein procalcitonin lactate neutrophil and lymphocyte values will be collected by scanning the hospital information system
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None