Ignite Creation Date:
2024-05-06 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 1:54 PM
Study NCT ID:
NCT04707365
Status:
NOT_YET_RECRUITING
Last Update Posted:
2021-01-13
First Post:
2021-01-12
Brief Title:
Microenvironment and Immunity of Digestive Cancers - East Paris Multicentric Cohort
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Interactions Between Tumor Tumor Microenvironment and Immune System in Digestive Cancers Impact on Survival and Response to Treatment
Status:
NOT_YET_RECRUITING
Status Verified Date:
2020-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MICADO
Brief Summary:
Colorectal and pancreatobiliary cancers are the most common digestive cancers Their incidence has particularly increased over the last few decades leading to suspicion that environmental factors are involved In addition strategies for the therapeutic management of these cancers are evolving in the context of the development of immunotherapies
Tumor microenvironment is a potential source of new diagnostic prognostic and predictive markers and new therapeutic targets The links between tumor microenvironment and modulation of the immune system in colorectal and pancreatobiliary cancers are poorly understood Molecular classifications have been proposed for these cancers but their link with immunity and response to treatment remains to be explored
Objective explore links between molecular subtypes tumor microenvironment host immune system pre-metastatic niche intestinal microbiota metabolism and survival prognostic value response predictive value and tolerance toxicities to treatments in digestive cancers in particular colorectal and pancreatobiliary cancers
Method Retrospective and prospective monocentric cohort study
Tumor microenvironment is a potential source of new diagnostic prognostic and predictive markers and new therapeutic targets The links between tumor microenvironment and modulation of the immune system in colorectal and pancreatobiliary cancers are poorly understood Molecular classifications have been proposed for these cancers but their link with immunity and response to treatment remains to be explored
Objective explore links between molecular subtypes tumor microenvironment host immune system pre-metastatic niche intestinal microbiota metabolism and survival prognostic value response predictive value and tolerance toxicities to treatments in digestive cancers in particular colorectal and pancreatobiliary cancers
Method Retrospective and prospective monocentric cohort study
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| IDRCB 2019-A00071-56 | OTHER | ANSM | None |