Ignite Creation Date:
2024-05-06 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 1:53 PM
Study NCT ID:
NCT04706143
Status:
UNKNOWN
Last Update Posted:
2021-01-14
First Post:
2021-01-04
Brief Title:
Immunologic Responses to Single and Double Doses of COVID-19 Vaccines in Egyptians
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
T Cell Antibody and Cytokine Responses to Single and Double Doses of COVID-19 Vaccines in Egyptians
Status:
UNKNOWN
Status Verified Date:
2021-01
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The recent Coronavirus Disease 2019 COVID-19 has caused a global pandemic and development of safe effective vaccines is mandatory to return back to pre pandemic life Many vaccines have been developed and requested by the authorities after the emergency license issued The main mechanism of protection is through humoral and cell-mediated immune responses that might reduce the potential for disease development or severity Cytotoxic T cells clear virus-infected host cells and contribute to control of infection Preliminary data are now available indicating safty and effecacy of different vaccines The vaccines were tolerated with induction of neutralizing antibodies and antigen-specific T cells against the SARS-CoV-2 spike protein The aim of this work is to evaluate the immune responses in adults aged 25-65 years up to 8 weeks after vaccination with a single and double doses live inactivated Sinopharm mRNA Pfizer Biontech and viral vector OxfordAZ- ChAdOx1 nCoV-19 vaccines The Th1- response interferon-γ and tumor necrosis factor-α cytokine secretion by CD4 T cells and antibody production predominantly of IgG1 and IgG3 subclasses as well as CD8 T cells mono polyfunctional and cytotoxic phenotypes will be also measured
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None