Ignite Creation Date:
2024-05-05 @ 5:17 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00422851
Status:
COMPLETED
Last Update Posted:
2017-11-13
First Post:
2007-01-12
Brief Title:
Gas Supply Demand and Middle Ear Gas Balance Specific Aim 3c
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Gas Supply Demand and Middle Ear Gas Balance Specific Aim 3c
Status:
COMPLETED
Status Verified Date:
2017-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will determine if gas can pass between the environment and the middle ear by way of the eardrum This route of gas exchange was observed in animals but has not been studied in humans If gas exchange across the eardrum is documented and the rate is sufficiently high this can help explain certain past observations such as why middle ear pressure does not change very much in some children and adults when they have a cold or flu The investigators also expect that the rate of gas exchange across the eardrum will depend on whether or not the eardrum has scarred or abnormally thin regions
Detailed Description:
Middle-ear ME pressure is a measure of the number of contained gas moles and processes that addd or remove gas moles from the relatively fixed volume ME cavity change its pressure Experimental results from animal studies document significant gas exchange across the tympanic membrane and if confirmed for humans may explain some of the paradoxical findings for children with poor Eustachian tube function such as the preservation of an aerated ME when the normal routes of gas supply are disrupted This study measures the rates of reactive and inert gas exchange across the adult tympanic membrane with and without structural abnormalities and determines if these transfers are purely diffusive phenomena The resulting data will be used to develop species-specific rate-constants that will be used as parameters in modeling ME pressure regulation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NIH P50DC007667 | None | None | None |