Ignite Creation Date:
2024-05-06 @ 3:38 PM
Last Modification Date:
2024-10-26 @ 1:53 PM
Study NCT ID:
NCT04690673
Status:
COMPLETED
Last Update Posted:
2021-12-08
First Post:
2020-12-14
Brief Title:
Detection of Paracetamol Concentration in Blood- Saline- and Urine Samples - a Validation Study for a Novel Technique
Sponsor:
Johanna Kujala
Organization:
Helsinki University Central Hospital
Study Overview
Official Title:
Detection of Paracetamol Concentration in Blood- Saline- and Urine Samples With an Electrochemical Indicator in Healthy Volunteers - a Validation Study for a Novel Technique
Status:
COMPLETED
Status Verified Date:
2021-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main objective is to assess whether a novel electrochemical tool is reliable in detecting concentration of paracetamol in fingerprick- saline- urine- and serum samples We will recruit 12 healthy volunteers aged 18-45 They will get 1 g oral paracetamol Paracetamol concentration will be detected from abovementioned samples at timely intervals for 24 hours analyzed with the novel electrochemical method and compared to gold standard mass-spectrometry analysis
Despite of extensive use the mechanism of action of parasetamol is not completely understood The central serotonergic system may play a role Endocannabinoid system is a group of lipid mediators that possibly is involved in mediating paracetamol effect to the serotonergic system Serum lipidomic assessment can be used to study endocannabinoid metabolics In this study we will try to assess changes in endocannabinoid system by looking into serum lipidomics in order to understand the mechanism of action of paracetamol
Despite of extensive use the mechanism of action of parasetamol is not completely understood The central serotonergic system may play a role Endocannabinoid system is a group of lipid mediators that possibly is involved in mediating paracetamol effect to the serotonergic system Serum lipidomic assessment can be used to study endocannabinoid metabolics In this study we will try to assess changes in endocannabinoid system by looking into serum lipidomics in order to understand the mechanism of action of paracetamol
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None