Ignite Creation Date:
2024-05-06 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 1:53 PM
Study NCT ID:
NCT04694131
Status:
COMPLETED
Last Update Posted:
2023-10-16
First Post:
2021-01-01
Brief Title:
Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory
Status:
COMPLETED
Status Verified Date:
2023-10-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background
Transcranial magnetic stimulation TMS of the brain has been used to change the activity and
connections in the brain to improve memory Researchers are interested in how these brain changes cause memory improvements and how activity at the time of stimulation may change the effects of TMS
Objective
To learn how brain stimulation can be used to improve memory
Eligibility
Healthy adults ages 18-40
Design
Participants will be screened with a medical record review
Participants will have 3 study visits
At visit 1 participants will have a physical exam and will talk about their health They will have magnetic resonance imaging MRI The MRI scanner is a metal cylinder surrounded by a strong magnetic field During the MRI participants will lie on a table that can slide in and out of the scanner A coil will be placed over the head Participants will be asked to keep their eyes focused on a small cross on a computer screen inside the scanner The scanner makes loud noises Participants will get earplugs
At visits 2 and 3 participants will have TMS and perform tasks For TMS a wire coil encased in plastic is held on the scalp When the coil is triggered a brief electrical current passes through the coil and creates a magnetic pulse that stimulates the brain During TMS an electroencephalogram EEG will record brain activity For the EEG a cloth cap with electrodes is fitted on the participant s head Participants will complete a memory task and a spatial processing task They will also complete surveys about their mental state
Participation will last 2-3 weeks
Transcranial magnetic stimulation TMS of the brain has been used to change the activity and
connections in the brain to improve memory Researchers are interested in how these brain changes cause memory improvements and how activity at the time of stimulation may change the effects of TMS
Objective
To learn how brain stimulation can be used to improve memory
Eligibility
Healthy adults ages 18-40
Design
Participants will be screened with a medical record review
Participants will have 3 study visits
At visit 1 participants will have a physical exam and will talk about their health They will have magnetic resonance imaging MRI The MRI scanner is a metal cylinder surrounded by a strong magnetic field During the MRI participants will lie on a table that can slide in and out of the scanner A coil will be placed over the head Participants will be asked to keep their eyes focused on a small cross on a computer screen inside the scanner The scanner makes loud noises Participants will get earplugs
At visits 2 and 3 participants will have TMS and perform tasks For TMS a wire coil encased in plastic is held on the scalp When the coil is triggered a brief electrical current passes through the coil and creates a magnetic pulse that stimulates the brain During TMS an electroencephalogram EEG will record brain activity For the EEG a cloth cap with electrodes is fitted on the participant s head Participants will complete a memory task and a spatial processing task They will also complete surveys about their mental state
Participation will last 2-3 weeks
Detailed Description:
Study Description
The Behavioral Neurology Unit studies the human brain systems underlying learning and adaptation with the goal of finding interventions to make these processes more efficient In this study we are interested in examining how the task state of the episodic memory network influences the effect of faciliatory TMS on memory and its EEG neural correlates It is hypothesized that Network-targeted parietal-TMS will improve memory performance and enhance EEG biomarkers of successful memory performance but that these changes will be modulated by the ongoing task activity
during stimulation
Objectives
Primary Objectives
Investigate how TMS modulates EEG neural measures of successful memory and the association of this modulation with behavioral performance
Examine how memory task state influences susceptibility to plasticity via TMS and determine the optimal neural state for improving memory
Exploratory Objectives
-Search for MRI predictors of the effects of TMS
Endpoints
Primary Endpoints Memory performance Late Positive Posterior ERP evoked thetaalpha power secondary EEG functional connectivity secondary
Exploratory Endpoints fMRI resting state functional connectivity fractional anisotropy
The Behavioral Neurology Unit studies the human brain systems underlying learning and adaptation with the goal of finding interventions to make these processes more efficient In this study we are interested in examining how the task state of the episodic memory network influences the effect of faciliatory TMS on memory and its EEG neural correlates It is hypothesized that Network-targeted parietal-TMS will improve memory performance and enhance EEG biomarkers of successful memory performance but that these changes will be modulated by the ongoing task activity
during stimulation
Objectives
Primary Objectives
Investigate how TMS modulates EEG neural measures of successful memory and the association of this modulation with behavioral performance
Examine how memory task state influences susceptibility to plasticity via TMS and determine the optimal neural state for improving memory
Exploratory Objectives
-Search for MRI predictors of the effects of TMS
Endpoints
Primary Endpoints Memory performance Late Positive Posterior ERP evoked thetaalpha power secondary EEG functional connectivity secondary
Exploratory Endpoints fMRI resting state functional connectivity fractional anisotropy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 000196-N | None | None | None |