Ignite Creation Date:
2024-05-06 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 1:52 PM
Study NCT ID:
NCT04686435
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-02-07
First Post:
2020-12-22
Brief Title:
Metabolic Syndrome and Persistent Shoulder Pain 1 Year After Primary Diagnosis
Sponsor:
Vejle Hospital
Organization:
Vejle Hospital
Study Overview
Official Title:
Metabolic Syndrome and Persistent Shoulder Pain 1 Year After Primary Diagnosis The Prospective Vejle Hospital Shoulder Cohort VHS Cohort With Focus on Prognostic Factors
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In a longitudinal cohort project the objective is to evaluate general prognostic and individual risk factors for long lasting shoulder pain with a specific focus on evaluation of the association between metabolic syndrome and tendinopathy while simultaneous adjusting for other potential prognostic candidate variables PROGRESS Theme I-II
Detailed Description:
The VHS Cohort is a prospective cohort trial evaluating a wide range of patient reported and clinical prognostic factors attained prior to initiation of treatment among shoulder patients referred for diagnostic evaluation at the specialized shoulder unit at Vejle Hospital Denmark The department receives approximately 2000 new patients each year
Prior to medical examination patients will be asked to fill in a baseline questionnaire and from the electronic patient record a range of different clinical factors will be obtained
Subsequently patients will be asked to answer questionnaires on patient reported outcomes after 1 3 6 and 12 months Five years after inclusion into the trial work affiliation will be retrieved from registries in order to evaluate association between shoulder disorders and work affiliation
The objective of the VHS Cohort Project is to evaluate general prognostic and individual risk factors for long lasting shoulder pain A specific focus is evaluation of the association between metabolic syndrome and rotator cuff tendinopathy while simultaneously adjusting for other potential prognostic candidate variables PROGRESS Theme I-II In a subsequent cohort VHS Cohort Project II the objective will be to develop a prognostic model for the treatment effect of Rotator Cuff Related Shoulder Pain RCRSP PROGRESS Theme III
VHS Cohort Project I
Aim 1 Evaluate the risk of consistent pain one year after diagnosis among patients diagnosed with RCRSP Rotator cuff lesions conservatively treated Acromioclavicular osteoarthritis and Adhesive capsulitis PROGRESS Theme I
Aim 2 Evaluate the risk of consistent pain one year after surgery for subacromial Decompression OR Rotator Cuff lesion PROGRESS Theme I
Aim 3 Evaluate the risk of consistent pain one year after diagnosis in patients with metabolic syndrome compared to patients without metabolic syndrome with particular emphasis on patients diagnosed with RCRSP while simultaneously adjusting for other potential prognostic candidate variables PROGRESS Theme II
We hypothesize that
Significantly more patients with RCRSP have metabolic syndrome than patients diagnosed with other shoulder-specific diagnoses
Significantly more patients with metabolic syndrome and diagnosed with RCRSP are classified as non-responders to treatment than patients with other shoulder specific diagnoses 52 weeks after initial medical examination
Significantly more shoulder patients with metabolic syndrome report multiple musculoskeletal pain sites than shoulder patients without metabolic syndrome at first medical examination
Aim 4 From clinical examination findings and patient reported information identify the strongest individual predictors of prognostic value for persistent shoulder pain and disability one year after initial medical examination in patients with rotator cuff related pain syndrome RCRSP Diagnostic codes DM751 DM751A DM751B DM754 DM755 DM758 DM759 treated conservatively with either exercise corticosteroid injection or a combination of the two while simultaneously adjusting for other potential prognostic candidate variables PROGRESS Theme II
Aim 5 From clinical examination findings and patient reported information identify the strongest individual preoperative predictors of prognostic value for persistent shoulder pain and disability one year after surgery for patients receiving SubAcromial Decompression SAD surgery Procedure code KNBH51 while simultaneous adjusting for other potential prognostic candidate variables PROGRESS Theme II
Aim 6 From clinical examination findings and patient reported information identify the strongest individual predictors of five-year work participation rates
Prior to medical examination patients will be asked to fill in a baseline questionnaire and from the electronic patient record a range of different clinical factors will be obtained
Subsequently patients will be asked to answer questionnaires on patient reported outcomes after 1 3 6 and 12 months Five years after inclusion into the trial work affiliation will be retrieved from registries in order to evaluate association between shoulder disorders and work affiliation
The objective of the VHS Cohort Project is to evaluate general prognostic and individual risk factors for long lasting shoulder pain A specific focus is evaluation of the association between metabolic syndrome and rotator cuff tendinopathy while simultaneously adjusting for other potential prognostic candidate variables PROGRESS Theme I-II In a subsequent cohort VHS Cohort Project II the objective will be to develop a prognostic model for the treatment effect of Rotator Cuff Related Shoulder Pain RCRSP PROGRESS Theme III
VHS Cohort Project I
Aim 1 Evaluate the risk of consistent pain one year after diagnosis among patients diagnosed with RCRSP Rotator cuff lesions conservatively treated Acromioclavicular osteoarthritis and Adhesive capsulitis PROGRESS Theme I
Aim 2 Evaluate the risk of consistent pain one year after surgery for subacromial Decompression OR Rotator Cuff lesion PROGRESS Theme I
Aim 3 Evaluate the risk of consistent pain one year after diagnosis in patients with metabolic syndrome compared to patients without metabolic syndrome with particular emphasis on patients diagnosed with RCRSP while simultaneously adjusting for other potential prognostic candidate variables PROGRESS Theme II
We hypothesize that
Significantly more patients with RCRSP have metabolic syndrome than patients diagnosed with other shoulder-specific diagnoses
Significantly more patients with metabolic syndrome and diagnosed with RCRSP are classified as non-responders to treatment than patients with other shoulder specific diagnoses 52 weeks after initial medical examination
Significantly more shoulder patients with metabolic syndrome report multiple musculoskeletal pain sites than shoulder patients without metabolic syndrome at first medical examination
Aim 4 From clinical examination findings and patient reported information identify the strongest individual predictors of prognostic value for persistent shoulder pain and disability one year after initial medical examination in patients with rotator cuff related pain syndrome RCRSP Diagnostic codes DM751 DM751A DM751B DM754 DM755 DM758 DM759 treated conservatively with either exercise corticosteroid injection or a combination of the two while simultaneously adjusting for other potential prognostic candidate variables PROGRESS Theme II
Aim 5 From clinical examination findings and patient reported information identify the strongest individual preoperative predictors of prognostic value for persistent shoulder pain and disability one year after surgery for patients receiving SubAcromial Decompression SAD surgery Procedure code KNBH51 while simultaneous adjusting for other potential prognostic candidate variables PROGRESS Theme II
Aim 6 From clinical examination findings and patient reported information identify the strongest individual predictors of five-year work participation rates
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None