Ignite Creation Date:
2024-05-06 @ 3:34 PM
Last Modification Date:
2024-10-26 @ 1:52 PM
Study NCT ID:
NCT04685018
Status:
UNKNOWN
Last Update Posted:
2020-12-28
First Post:
2020-12-14
Brief Title:
The Neurocircuitry of Relief During Avoidance Learning in Patients With Obsessive-compulsive Disorder
Sponsor:
KU Leuven
Organization:
KU Leuven
Study Overview
Official Title:
The Neurocircuitry of Relief During Avoidance Learning in Patients With Obsessive-compulsive Disorder
Status:
UNKNOWN
Status Verified Date:
2020-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AvoidOCD
Brief Summary:
To investigate the neuro-mechanisms underpinning persistent avoidance in OCD patients
Detailed Description:
Many compulsions displayed by obsessive-compulsive disorder OCD patients serve to protect against perceived threat and can therefore be conceptualized as avoidance responses Exposure treatment with response prevention ETRP is aimed at exposing patients to their obsessive thoughts and perceived threats while preventing engagement in compulsive avoidant responses This induces extinction of threat perception and fearful arousal and hence reduces the motivation to avoid While successful in many patients however as much as 40 dropout during treatment or display persistent avoidance after ETRP There is a clear need for treatment improvement for these often highly disabled patients
Improving ETRP outcomes requires a deeper understanding of the mechanisms that drive excessive and persistent avoidance in OCD patients Psychological theories ascribe an important role to the relief that follows avoidance when the anticipated threat is successfully averted This positive feeling arguably functions as a reward to reinforce the foregoing avoidance actions Indeed fMRI studies have found that the neurocircuitry of relief overlaps with that of reward including the ventral tegmental area ventral striatum and orbitofrontal cortex Here the authors will test the hypothesis that excessive-persistent avoidance is linked to exaggerated activation of the relief circuitry in OCD patients For that purpose we will acquire functional brain images of OCD patients in an MRI scanner and compare to healthy participants while they participate in a computer task that is designed to model avoidance learning and relief
Improving ETRP outcomes requires a deeper understanding of the mechanisms that drive excessive and persistent avoidance in OCD patients Psychological theories ascribe an important role to the relief that follows avoidance when the anticipated threat is successfully averted This positive feeling arguably functions as a reward to reinforce the foregoing avoidance actions Indeed fMRI studies have found that the neurocircuitry of relief overlaps with that of reward including the ventral tegmental area ventral striatum and orbitofrontal cortex Here the authors will test the hypothesis that excessive-persistent avoidance is linked to exaggerated activation of the relief circuitry in OCD patients For that purpose we will acquire functional brain images of OCD patients in an MRI scanner and compare to healthy participants while they participate in a computer task that is designed to model avoidance learning and relief
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None