Ignite Creation Date:
2024-05-06 @ 3:32 PM
Last Modification Date:
2024-10-26 @ 1:51 PM
Study NCT ID:
NCT04664205
Status:
COMPLETED
Last Update Posted:
2022-12-06
First Post:
2020-12-04
Brief Title:
Isoenergetic High Intensity Interval Training and Moderate Intensity Training in Adults With Type I Diabetes
Sponsor:
University of North Carolina Chapel Hill
Organization:
University of North Carolina Chapel Hill
Study Overview
Official Title:
Metabolic Hormonal and Physiological Characterization of Isoenergetic High Intensity Interval Training and Moderate Intensity Continuous Training in Adults With Type I Diabetes
Status:
COMPLETED
Status Verified Date:
2022-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HI1T
Brief Summary:
Type 1 diabetes T1D is associated with increased risk of poor cardiometabolic health Regular exercise is recommended for optimal management of comorbidities in T1D Unique barriers to exercise exist for T1D including fear of hypoglycemia unpredictable glycemic excursions with exercise and inadequate knowledge about exercise Unlike traditional moderate intensity continuous training MICT which requires extended periods of time high intensity interval training HIIT requires minimal time 10 minutes of exercise per session with the potential to rapidly stimulate mitochondrial biogenesis and metabolism The extent to which these exercise strategies alter metabolomic signatures of carbohydrate fat and amino acid metabolism in T1D is unknown The overall goal of the proposed project is to identify the acute metabolic effects and physiological modifiers of HIIT compared to MICT and control CON using metabolomic profiling and cardiometabolic assessments in 14 adults with T1D Using a randomized cross-over approach the primary aim is to compare the metabolomics response immediately post 1 hr post and glycemic control through 48 hrs after HIIT compared to MICT matched for total energy expenditure versus a no exercise CON An additional aim will be to characterize the influence of biological sex and physiological outcomes ie body composition lean mass visceral fat on the metabolomics profile of these subjects Outcomes from the present study with existing data from our team will lay the foundation for a larger diet and exercise lifestyle intervention that will ultimately lead to changes in clinical practice to co-manage glycemia and cardiometabolic comorbidities
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None