Ignite Creation Date:
2024-05-06 @ 3:32 PM
Last Modification Date:
2024-10-26 @ 1:51 PM
Study NCT ID:
NCT04661800
Status:
UNKNOWN
Last Update Posted:
2021-03-10
First Post:
2020-11-19
Brief Title:
Study of Olfactory Disorders in Patients With Cardiac Amyloidosis
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Prevalence and Characteristics of Alterations in Olfactory and Taste Function in Patients With Cardiac Amyloidosis and Nutritional Impact Multicenter Cross-sectional Study
Status:
UNKNOWN
Status Verified Date:
2020-11
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AMYLODOR
Brief Summary:
Amyloidosis is a disease caused by the continuous accumulation of fibrillary proteins in the extracellular matrix causing the architecture of different organs to be disrupted The prevalence of the disease increases with age The two most common forms are light chain amyloidosis AL and transthyretin TTR TTR amyloidosis may be hereditary m-TTR or mutated or age-related WT-TTR or wild The latter is also called senile amyloidosis In all these forms cardiac impairment is common and leads the patient to consultor be referred to a cardiological center unfortunately often too late when the prognosis is directly related to the severity of the heart attack The descriptiondiscovery of clinical signs prior to heart disease is important to improve the detection and diagnosis of early forms of cardiac amyloidosis CA For example an infiltration of the carpal tunnel synovial by amyloid deposits is observed in some patients 5 years before the onset of signs of heart failure and is the only warning sign of the disease known to date We also showed in a previous study that patients had more severe and earlier impairment of hearing function than expected by age and gender
Objective The main objective is to define the prevalence and severity of smell and taste disorders in a population of patients with cardiac amyloidosis 3 types of mutated or wild AL amyloidosis and TTR
The main endpoint is to determine the number of patients with impaired smell and tastes functions in a population of patients diagnosed with cardiac amyloidosis 3 types of mutated hereditary or senile wild amyloidosis 3 types of AL amyloidosis and TTR
Method Successive monocentric cross-sectional study on the screening of smell and taste disorders carried out as part of a cardiology hospitalization programmed for the cardiology follow-up of his pathology in a population of patients diagnosed with AC
Objective The main objective is to define the prevalence and severity of smell and taste disorders in a population of patients with cardiac amyloidosis 3 types of mutated or wild AL amyloidosis and TTR
The main endpoint is to determine the number of patients with impaired smell and tastes functions in a population of patients diagnosed with cardiac amyloidosis 3 types of mutated hereditary or senile wild amyloidosis 3 types of AL amyloidosis and TTR
Method Successive monocentric cross-sectional study on the screening of smell and taste disorders carried out as part of a cardiology hospitalization programmed for the cardiology follow-up of his pathology in a population of patients diagnosed with AC
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None