Ignite Creation Date:
2024-05-06 @ 3:32 PM
Last Modification Date:
2024-10-26 @ 1:51 PM
Study NCT ID:
NCT04664530
Status:
UNKNOWN
Last Update Posted:
2020-12-11
First Post:
2020-12-06
Brief Title:
The Study on the Esketamine in the Treatment of Postherpetic Neuralgia
Sponsor:
Second Affiliated Hospital School of Medicine Zhejiang University
Organization:
Second Affiliated Hospital School of Medicine Zhejiang University
Study Overview
Official Title:
The Study on the Esketamine in the Treatment of Postherpetic Neuralgia
Status:
UNKNOWN
Status Verified Date:
2020-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Herpes zoster HZ is an acute herpetic skin disease caused by the reactivation of the varicella-zoster virus VZV latent in the sensory ganglia Postherpetic neuralgia PHN often occurs after herpes zoster heals and persists for a long time At present clinically anticonvulsants such as gabapentin pregabalin and antidepressants such as amitriptyline are clinically first-line drugs for the treatment of PHN which are not usually effective to treat PHN well as well as to alleviate patients bad mental symptoms Esketamine as a well-known N-methyl-D-aspartate receptor inhibitor has both analgesic and antidepressant effects with extremely few incidence of respiratory depression delirium hallucinations nausea and vomiting Therefore we hypothesize that esketamine could relieve PHN and Anxiety and depression-like symptoms symptoms in patients with PHN This study intended to compare the efficacy of pregabalin amitriptyline combined with esketamine therapy and pregabalin combined with amitriptyline therapy for alleviating PHN and to further explore the feasibility and safety of esketamine in the treatment of PHN as well as underlying the mechanism of esketamine on the PHN
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None