Ignite Creation Date:
2024-05-06 @ 3:32 PM
Last Modification Date:
2024-10-26 @ 1:51 PM
Study NCT ID:
NCT04664322
Status:
COMPLETED
Last Update Posted:
2020-12-11
First Post:
2020-11-19
Brief Title:
High-flow Oxygen Therapy vs Non-invasive Ventilation Comparison of Alveolar Recruitment in Acute Respiratory Failure
Sponsor:
University Hospital Rouen
Organization:
University Hospital Rouen
Study Overview
Official Title:
High-flow Oxygen Therapy Versus Non-invasive Ventilation a Randomised Physiological Cross-over Study of Alveolar Recruitment in Acute Respiratory Failure
Status:
COMPLETED
Status Verified Date:
2020-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
IRAvista
Brief Summary:
This physiological study showed an increase in regional ventilation with NIV but no difference in alveolar recruitment as compared to HFNC in patients with hypoxemic ARF Although NIV provided better oxygenation than HFNC the effect on lung volumes could explain the potentially deleterious effect of NIV in hypoxemic ARF reinforcing the recently developed concept of patient self-inflicted lung injury
Detailed Description:
Background High-flow nasal cannula HFNC oxygen therapy has recently shown clinical benefits in hypoxemic acute respiratory failure ARF patients while the interest of non-invasive ventilation NIV remains debated The primary endpoint was to compare alveolar recruitment using global end-expiratory electrical lung impedance EELI between HFNC and NIV Secondary endpoints compared regional EELI lung volumes global and regional tidal volume variation TV respiratory parameters hemodynamic tolerance dyspnea and patient comfort between HFNC and NIV relative to face mask FM
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| CPP-CS 0012015 | OTHER | CPP Nord Ouest 1 | None |