Ignite Creation Date:
2024-05-06 @ 3:30 PM
Last Modification Date:
2024-10-26 @ 1:50 PM
Study NCT ID:
NCT04650737
Status:
UNKNOWN
Last Update Posted:
2020-12-03
First Post:
2020-11-13
Brief Title:
Single-Shot With Dexmedetomidine Versus Continuous Ultrasound-guided Erector Spinae Plane Block for Postoperative Pain Control After Percutaneous Nephrolithotomy
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Single-Shot With Dexmedetomidine Versus Continuous Ultrasound-guided Erector Spinae Plane Block for Postoperative Pain Control After Percutaneous Nephrolithotomy Prospective Randomized Clinical Trial
Status:
UNKNOWN
Status Verified Date:
2020-12
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The current study is designed to assess the efficacy of a single shot ESPB with Dexmedetomidineversus continuous ESPB in perioperative analgesia for PCNL Both techniques are conducted for patients undergoing PCNL under GA
Detailed Description:
Successful perioperative pain management is one of the main goals of the whole anesthetic practice Kidney Surgeries especially those involving the renal pelvis warrant special analgesic considerations This is due to the sensitivity of the renal pelvis to pain Its sub-diaphragmatic position affects deep breathing and coughing Which renders adequate analgesia an important factor for maintaining good respiratory force and depth postoperative and reduces respiratory complications like atelectasis
The Use of a single mode of analgesia in these settings like the use of parenteral opioids for example provides significantly less analgesic effect and more complications including respiratory depression PONV postoperative nausea and vomiting constipation urine retention etc
The use of regional techniques as a part of multimodal pain management in these procedures provides superior analgesia and less complication rates
This is added to high expectations of an easier perioperative course of PCNL percutaneous nephrolithotomy being and endoscopic procedure that does not involve a big skin incision These expectations also include a short hospital stay However PCNL is usually associated with significant pain and discomfort postoperatively Various studies have been studying effects of integrating local and regional techniques in the perioperative pain management
For Regional and local procedures of analgesia Studies of Single Shot technique and catheter techniques has long been ongoing for many regional techniques for example like Pravertebral block and adductor canal block These studies are conducted to determine the efficacy and adversities each technique
Alpha-2 adrenoceptor agonists such as clonidine have been shown to increase the duration of peripheral nerve block Dexmedetomidine is a more potent and selective α-2-adrenoceptor compared to clonidine Peri-neural dexmedetomidine was evaluated in animal studies where it prolonged the duration of sensory and motor blocks of local anesthetics without any evidence of neurotoxicity for up to 14 days after initial administration The use of perineuraldexmedetomidine prolong the duration of of sensory block provide effective acute pain control after surgery and reduce the need for rescue analgesia in several nerve blocks like upper limb extremity blocksParavertebral block tranversus abdominis plane TAP block and Erector spinae plane block
Erector spinae plane block ESPB is a relatively novel procedure The limited number of studies available show promising results as regards the efficacy of pain management in trunk surgeries and renal interventions However the studies that clarify the different applications of ESPB including the efficacy of a single shot versus a continuous block with an indwelling catheter are lacking
The Use of a single mode of analgesia in these settings like the use of parenteral opioids for example provides significantly less analgesic effect and more complications including respiratory depression PONV postoperative nausea and vomiting constipation urine retention etc
The use of regional techniques as a part of multimodal pain management in these procedures provides superior analgesia and less complication rates
This is added to high expectations of an easier perioperative course of PCNL percutaneous nephrolithotomy being and endoscopic procedure that does not involve a big skin incision These expectations also include a short hospital stay However PCNL is usually associated with significant pain and discomfort postoperatively Various studies have been studying effects of integrating local and regional techniques in the perioperative pain management
For Regional and local procedures of analgesia Studies of Single Shot technique and catheter techniques has long been ongoing for many regional techniques for example like Pravertebral block and adductor canal block These studies are conducted to determine the efficacy and adversities each technique
Alpha-2 adrenoceptor agonists such as clonidine have been shown to increase the duration of peripheral nerve block Dexmedetomidine is a more potent and selective α-2-adrenoceptor compared to clonidine Peri-neural dexmedetomidine was evaluated in animal studies where it prolonged the duration of sensory and motor blocks of local anesthetics without any evidence of neurotoxicity for up to 14 days after initial administration The use of perineuraldexmedetomidine prolong the duration of of sensory block provide effective acute pain control after surgery and reduce the need for rescue analgesia in several nerve blocks like upper limb extremity blocksParavertebral block tranversus abdominis plane TAP block and Erector spinae plane block
Erector spinae plane block ESPB is a relatively novel procedure The limited number of studies available show promising results as regards the efficacy of pain management in trunk surgeries and renal interventions However the studies that clarify the different applications of ESPB including the efficacy of a single shot versus a continuous block with an indwelling catheter are lacking
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None