Ignite Creation Date:
2024-05-06 @ 3:30 PM
Last Modification Date:
2024-10-26 @ 1:50 PM
Study NCT ID:
NCT04651556
Status:
COMPLETED
Last Update Posted:
2020-12-08
First Post:
2020-11-12
Brief Title:
Intraperitoneal Magnesium Sulphate and Bupivacaine Versus Intravenous Analgesia in Laparoscopic Surgeries in Pediatrics
Sponsor:
Menoufia University
Organization:
Menoufia University
Study Overview
Official Title:
Comparison Of Intraperitoneal Instillation Of Magnesium Sulphate and Bupivacaine Versus Intravenous Analgesia In Laparoscopic Surgeries In Pediatrics
Status:
COMPLETED
Status Verified Date:
2020-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators are going to study the analgesic efficacy of intraperitoneal instillation of a combination of Magnesium sulphate with bupivacaine versus ordinary used parenteral analgesics for pain relief after laparoscopic surgeries in pediatrics
Detailed Description:
Laparoscopic surgery is a modern surgical technique used for various surgeries such as cholecystectomy appendectomy and hernia repair There are a number of advantages of this technique including reduced pain and bleeding shorter recovery time and hospital stay and over all reduced healthcare costs The type of pain after laparoscopic surgery differs considerably from that occurs after laparotomy Usually patients experience diffuse pain in abdomen back and shoulder Acute pain after laparoscopic cholecystectomy has three different components incisional pain somatic pain visceral pain deep intra-abdominal pain and shoulder pain presumably referred visceral pain Postoperative nausea and vomiting is a commonly observed phenomenon after laparoscopic procedures Its incidence increases depending on the anesthetic techniques used Pain intensity usually peaks during the first postoperative period and usually declines over the following 2-3 days Pain can prolong hospital stay and lead to increased morbidity
Inadequately treated pain may lead to splinting loss of sighing and decrease in vital capacity and these may contribute to postoperative pulmonary morbidity Various multimodal approaches have therefore been tried to ameliorate postoperative pain These include parenteral analgesics local infiltration with local anesthetics epidural and intrathecal opioids and local anesthetics interpleural and intercostals nerve blocks as well as intraperitoneal routes that in turn has been explored with local anesthetics and opioids In order to get an instant relief polypharmacy is commonly practiced which can be potentially harmful to the patient and can lead to re-admission It has been appreciated that multiple glutamate receptors are expressed on peripheral nerve terminals and these may contribute to peripheral nociceptive sensation
Administration of magnesium sulphate via different routes has been used in anaesthetic practice for decreasing perioperative pain Parenteral magnesium sulphate has been used for many years as an antiarrhythmic agent and for seizure prophylaxis in eclampsia and preeclampsia It is N-methyl d-aspartate NMDA receptor antagonist and suppresses these receptor induced inflammation and hyper responsiveness The antinociceptive effect of magnesium sulphate is not only useful in chronic pain but it also determines in part the duration and intensity of postoperative pain These effects are due to calcium antagonism and decrease influx of calcium into the cell and antagonism of NMDA receptor As these receptors regulate neuronal signalling and are involved in pain processing magnesium sulphate by blocking this receptor decreases postoperative pain as well
Inadequately treated pain may lead to splinting loss of sighing and decrease in vital capacity and these may contribute to postoperative pulmonary morbidity Various multimodal approaches have therefore been tried to ameliorate postoperative pain These include parenteral analgesics local infiltration with local anesthetics epidural and intrathecal opioids and local anesthetics interpleural and intercostals nerve blocks as well as intraperitoneal routes that in turn has been explored with local anesthetics and opioids In order to get an instant relief polypharmacy is commonly practiced which can be potentially harmful to the patient and can lead to re-admission It has been appreciated that multiple glutamate receptors are expressed on peripheral nerve terminals and these may contribute to peripheral nociceptive sensation
Administration of magnesium sulphate via different routes has been used in anaesthetic practice for decreasing perioperative pain Parenteral magnesium sulphate has been used for many years as an antiarrhythmic agent and for seizure prophylaxis in eclampsia and preeclampsia It is N-methyl d-aspartate NMDA receptor antagonist and suppresses these receptor induced inflammation and hyper responsiveness The antinociceptive effect of magnesium sulphate is not only useful in chronic pain but it also determines in part the duration and intensity of postoperative pain These effects are due to calcium antagonism and decrease influx of calcium into the cell and antagonism of NMDA receptor As these receptors regulate neuronal signalling and are involved in pain processing magnesium sulphate by blocking this receptor decreases postoperative pain as well
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None