Ignite Creation Date:
2024-05-05 @ 5:15 PM
Last Modification Date:
2024-10-26 @ 9:29 AM
Study NCT ID:
NCT00410085
Status:
COMPLETED
Last Update Posted:
2008-04-22
First Post:
2006-12-10
Brief Title:
Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls
Sponsor:
Regional Hospital Holstebro
Organization:
Regional Hospital Holstebro
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2008-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Nitrogen-oxide NO plays an important role for blood pressure regulation renal hemodynamics and the renal excretion of sodium NO is synthesized from L-arginine in the vascular endothelium and have a very short half-life in plasma and is therefore very difficult to measure directly
L-mono-methyl-L-arginine L-NMMA is an analogue to L-arginine and a competitive inhibitor of NO and therefore can be used to study the effect of NO on the circulation In normal subjects infusion of L-NMMA will cause an increase in blood pressure decreased renal plasma-flow decreased glomerular filtration rate and a decreased excretion of sodium
Hypothesis Patients with obstructive sleep apnea has a decreased activity in the NO-system This is contributing to the hypertension often seen in these patients Decreased activity in the NO-system can be revealed by diminished fall in renal hemodynamic and sodium excretion after infusion of L-NMMA
L-mono-methyl-L-arginine L-NMMA is an analogue to L-arginine and a competitive inhibitor of NO and therefore can be used to study the effect of NO on the circulation In normal subjects infusion of L-NMMA will cause an increase in blood pressure decreased renal plasma-flow decreased glomerular filtration rate and a decreased excretion of sodium
Hypothesis Patients with obstructive sleep apnea has a decreased activity in the NO-system This is contributing to the hypertension often seen in these patients Decreased activity in the NO-system can be revealed by diminished fall in renal hemodynamic and sodium excretion after infusion of L-NMMA
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None