Viewing Study NCT00410085



Ignite Creation Date: 2024-05-05 @ 5:15 PM
Last Modification Date: 2024-10-26 @ 9:29 AM
Study NCT ID: NCT00410085
Status: COMPLETED
Last Update Posted: 2008-04-22
First Post: 2006-12-10

Brief Title: Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls
Sponsor: Regional Hospital Holstebro
Organization: Regional Hospital Holstebro

Study Overview

Official Title: None
Status: COMPLETED
Status Verified Date: 2008-04
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: Nitrogen-oxide NO plays an important role for blood pressure regulation renal hemodynamics and the renal excretion of sodium NO is synthesized from L-arginine in the vascular endothelium and have a very short half-life in plasma and is therefore very difficult to measure directly

L-mono-methyl-L-arginine L-NMMA is an analogue to L-arginine and a competitive inhibitor of NO and therefore can be used to study the effect of NO on the circulation In normal subjects infusion of L-NMMA will cause an increase in blood pressure decreased renal plasma-flow decreased glomerular filtration rate and a decreased excretion of sodium

Hypothesis Patients with obstructive sleep apnea has a decreased activity in the NO-system This is contributing to the hypertension often seen in these patients Decreased activity in the NO-system can be revealed by diminished fall in renal hemodynamic and sodium excretion after infusion of L-NMMA
Detailed Description: None

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: None
Is a FDA Regulated Device?: None
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None