Ignite Creation Date:
2024-05-06 @ 3:30 PM
Last Modification Date:
2024-10-26 @ 1:50 PM
Study NCT ID:
NCT04651010
Status:
RECRUITING
Last Update Posted:
2023-02-08
First Post:
2020-11-25
Brief Title:
Predictive Multimodal MRI Factors in Subacute Cerebral Artery Occlusiontreated by Thrombectomy PIMISUTT
Sponsor:
Poitiers University Hospital
Organization:
Poitiers University Hospital
Study Overview
Official Title:
Predictive Multimodal MRI Factors in Subacute Cerebral Artery Occlusiontreated by Thrombectomy PIMISUTT
Status:
RECRUITING
Status Verified Date:
2023-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PIMISUTT
Brief Summary:
Our study aims to measure metabolic and functional parameters of the infarcted territory by multimodal cerebral MRI in patients diagnosed with unilateral proximal occlusion of the middle cerebral artery and treated by thrombectomy in order to correlate those parameters to clinical outcome evaluated by modified Rankin score at 3 months
We aim to find early radiologic predictive factors for favorable clinical outcome in this population of patients
We aim to find early radiologic predictive factors for favorable clinical outcome in this population of patients
Detailed Description:
The treatment of acute ischemic stroke in the setting of intracranial large artery occlusion and especially middle cerebral artery occlusion MCAO with intravenous tissue plasminogen activator IV-tPA is associated with low rates of recanalization and high rates of neurological morbidity and functional dependence
In the last few years endovascular intervention mechanical thrombectomy has proven its safety and its efficacy on clinical outcome in patients diagnosed with MCAO and is now commonly recommended
However in this population of patients treated by thrombectomy very few predictive factors except for the post-procedural recanalization score TICI do exist to foresee the variability of clinical outcome
Tissue viability of the infarcted territory can be approached by the measure of metabolic and morphological parameters Na H phosphore diffusion imaging which can be non-invasively done by multimodal MRI as suggest by recently published studies
Our study plans to measure these parameters between 12 and 24 hours after acute ischemic stroke in patients with MCAO treated by thrombectomy in order to correlate those parameters to clinical outcome at 3 months modifier Rankin Score
In the last few years endovascular intervention mechanical thrombectomy has proven its safety and its efficacy on clinical outcome in patients diagnosed with MCAO and is now commonly recommended
However in this population of patients treated by thrombectomy very few predictive factors except for the post-procedural recanalization score TICI do exist to foresee the variability of clinical outcome
Tissue viability of the infarcted territory can be approached by the measure of metabolic and morphological parameters Na H phosphore diffusion imaging which can be non-invasively done by multimodal MRI as suggest by recently published studies
Our study plans to measure these parameters between 12 and 24 hours after acute ischemic stroke in patients with MCAO treated by thrombectomy in order to correlate those parameters to clinical outcome at 3 months modifier Rankin Score
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2020-A021118-31 | REGISTRY | ID-RBC | None |