Ignite Creation Date:
2024-05-06 @ 3:29 PM
Last Modification Date:
2024-10-26 @ 1:50 PM
Study NCT ID:
NCT04646902
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2023-12-07
First Post:
2020-10-12
Brief Title:
KynurenineTryptophan Ratio in Hypertension Associated to Obstructive Sleep Apnea
Sponsor:
Universidade Nova de Lisboa
Organization:
Universidade Nova de Lisboa
Study Overview
Official Title:
Relevance of the Ratio KynurenineTryptophan to Characterize Hypertension Associated to Obstructive Sleep Apnea KYNTOSA
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
KYNTOSA
Brief Summary:
Obstructive Sleep Apnea OSA is an independent risk factor for hypertension HTN and the most common cause of resistant HTN The mechanisms underlying OSA-associated HTN are not completely understood This is crucial to find novel therapeutic targets of OSA-associated HTN The Aryl Hydrocarbon Receptor AHR is a cytosolic transcription factor that has been linked with the pathogenesis of HTN
This study aims to evaluate the role of endogenous ligands of AHR such as kynurenine in discriminating patients with OSA-associated HTN For that aim a case-control study will be performed in patients with and without hypertension exposed and not exposed to OSA Kynurenine and other metabolites will be quantified in urine and serum samples
This study aims to evaluate the role of endogenous ligands of AHR such as kynurenine in discriminating patients with OSA-associated HTN For that aim a case-control study will be performed in patients with and without hypertension exposed and not exposed to OSA Kynurenine and other metabolites will be quantified in urine and serum samples
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| PTDCMED-TOX304182017 | OTHER_GRANT | Fundação para a Ciência e a Tecnologia | None |