Ignite Creation Date:
2024-05-06 @ 3:28 PM
Last Modification Date:
2024-10-26 @ 1:50 PM
Study NCT ID:
NCT04647279
Status:
UNKNOWN
Last Update Posted:
2021-04-06
First Post:
2020-11-27
Brief Title:
New MRI Sequences in Spine and Joint
Sponsor:
Fifth Affiliated Hospital Sun Yat-Sen University
Organization:
Fifth Affiliated Hospital Sun Yat-Sen University
Study Overview
Official Title:
Clinical Study of New MRI Sequences in Spine and Joint
Status:
UNKNOWN
Status Verified Date:
2021-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NMSSJ
Brief Summary:
Low back pain and osteoarticular degeneration or injury is the leading worldwide cause of years lost to disability accounting for 17 of all patients with disabilities and its burden is growing alongside the increasing and aging population The anatomical regions of the intervertebral disc include the central nucleus pulposus the peripheral fibrocartilaginous annulus fibrosus and the superior and inferior cartilaginous endplates CEP The CEP is a thin layer of hyaline cartilage located between the avascular intervertebral disc and the bony vertebral endplate The endplate cartilage consists of chondrocytes interspersed throughout an extracellular matrix of proteoglycans collagen types I and II and water It plays an important role in the function and homeostasis The CEP has been considered the pathway between the largely avascular disk tissues and the blood supply of the vertebral body and thus provides nutrition for disk cells Many musculoskeletal tissues including the CEP cartilage-bone interface of articular joints entheses tendons and ligaments have components with very short T2 values much less than 1 msec which are orders of magnitude shorter than that of the nucleus of the disk 100 msec In a conventional pulse sequence such as proton density-weighted spin-echo SE or fast SE with standard clinical section profile the minimum echo time TE is typically 10 msec which is much longer than that needed to capture the short-lived signal from these tissues Recently ultrashort echo sequence UTE technology has been introduced and the TE time can be as low as 0008ms This range of TE is sufficient to capture signals from the cartilage endplate before it decays With using new MRI technology such as IR-UTE UTE-MT UTE-T2mapping Maigc DTI and IVIM which can quantitative tissues that have previously been invisible at conventional MR imaging and provide imaging basis for early diagnosis of injury at molecular level The purpose of this study was to investigate the clinical application value of different MRI sequences in spine and joint
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None