Ignite Creation Date:
2024-05-06 @ 3:27 PM
Last Modification Date:
2024-10-26 @ 1:49 PM
Study NCT ID:
NCT04633746
Status:
COMPLETED
Last Update Posted:
2020-11-18
First Post:
2020-11-11
Brief Title:
Plasma Endostatin Predicts Outcome of Septic AKI
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Validation of Plasma Endostatin for Predicting Renal Outcome From Acute Kidney Injury Induced by Sepsis
Status:
COMPLETED
Status Verified Date:
2020-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Introduction Acute kidney injury AKI occurs up to 50 of patients admitted to intensive care unit Plasma Endostatin released from basement membrane of Bowmans capsule rises early during AKI
Aim of Work To investigate the role of the plasma endostatin in the outcome prediction renal recovery ICU stay mortality of acute kidney injury in patients with sepsis
Methods a prospective observational single center study on 40 patients with Sepsis at the Critical Care Department Cairo University hospitals between March 2019 and November 2019 Serum plasma endostatin was measured at the day of admission every 48hrs 3 samples APACHE II SOFA scores were calculated Forced diuresis was used if indicated
Aim of Work To investigate the role of the plasma endostatin in the outcome prediction renal recovery ICU stay mortality of acute kidney injury in patients with sepsis
Methods a prospective observational single center study on 40 patients with Sepsis at the Critical Care Department Cairo University hospitals between March 2019 and November 2019 Serum plasma endostatin was measured at the day of admission every 48hrs 3 samples APACHE II SOFA scores were calculated Forced diuresis was used if indicated
Detailed Description:
The study was conducted on 40 patients with sepsis who admitted in the Critical Care department of Cairo University
The sepsis is identified according to surviving sepsis campaign guidelines with use of SOFA score to establish the diagnosis
The patients divided into 2 groups the first group included 25 patients who developed AKI as defined by KDIGO guidelines and the other group included 15 patients as a control group
The Plasma Endostatin level is sampled in the first 24 hours of diagnosis of AKI the estimation of plasma Endostatin level done by ELISA technique
The results were presented in form of descriptive analytical and comparative data between the groups of study
It was found that the patients with higher levels of plasma endostatin had a higher incidence of recovery from AKI and higher incidence of 28 days survival while the patients with lower levels of plasma Endostatin below the determined Cut-off value have increased incidence of RRT
Also that the patients with higher levels of plasma Endostatin levels were less labile to mechanical ventilation and had a higher incidence of weaning of vasopressors in comparison of the other group of lower levels of plasma Endostatin
Plasma Endostatin levels have no difference between the AKI group and sepsis group which may need further investigations to determine its role in sepsis
so that the plasma Endostatin can be used as a marker of recovery from AKI
The sepsis is identified according to surviving sepsis campaign guidelines with use of SOFA score to establish the diagnosis
The patients divided into 2 groups the first group included 25 patients who developed AKI as defined by KDIGO guidelines and the other group included 15 patients as a control group
The Plasma Endostatin level is sampled in the first 24 hours of diagnosis of AKI the estimation of plasma Endostatin level done by ELISA technique
The results were presented in form of descriptive analytical and comparative data between the groups of study
It was found that the patients with higher levels of plasma endostatin had a higher incidence of recovery from AKI and higher incidence of 28 days survival while the patients with lower levels of plasma Endostatin below the determined Cut-off value have increased incidence of RRT
Also that the patients with higher levels of plasma Endostatin levels were less labile to mechanical ventilation and had a higher incidence of weaning of vasopressors in comparison of the other group of lower levels of plasma Endostatin
Plasma Endostatin levels have no difference between the AKI group and sepsis group which may need further investigations to determine its role in sepsis
so that the plasma Endostatin can be used as a marker of recovery from AKI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None